DegronMD - Q99550(MPHOSPH9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P887S	TCGA-21-1079	LUSC	TCGA	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation altering degron motif	0.5641
p.R876H	TCGA-2W-A8YY	CESC	TCGA	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.25
p.E219K	TCGA-4Z-AA81	BLCA	TCGA	DSGTGLT	DEG_SCF_TRCP1_1	207:213	Mutation rewiring degron network	0.1667
p.S836P	TCGA-AP-A054	UCEC	TCGA	PKENL	DEG_APCC_KENBOX_2	837:841	Mutation blocking phosphorylation signal	0.75
p.K719R	TCGA-AP-A1DK	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation substituting flanking lysine	0.3333
p.D221V	TCGA-BR-8487	STAD	TCGA	DSGTGLT	DEG_SCF_TRCP1_1	207:213	Mutation rewiring degron network	0.1111
p.P723H	TCGA-D3-A2JC	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.7694
p.S832T	TCGA-DM-A1D8	COAD	TCGA	PKENL	DEG_APCC_KENBOX_2	837:841	Mutation blocking phosphorylation signal	0.6389
p.V869I	TCGA-EO-A3AU	UCEC	TCGA	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.0556
p.V869F	TCGA-L9-A7SV	LUAD	TCGA	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.0556
p.E216Q	DO223599	BLCA	ICGC	DSGTGLT	DEG_SCF_TRCP1_1	207:213	Mutation substituting flanking lysine	0.3611
p.E728Q	DO465	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.3056
p.K733N	DO50090	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation substituting flanking lysine	0.2778
p.N737H	DO8858	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.0556
p.S724F	DO233114	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.7982
p.S724F	DO222363	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation altering degron motif	0.7982
p.D717N	DO22295	LGG	ICGC	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1667
p.L872V	DO44569	LGG	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.1389
p.D889E	DO229045	LICA	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.2778
p.Q897H	DO45475	LUSC	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.0556
p.Q897H	DO219773	UCEC	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.0556
p.Q897H	DO42793	UCEC	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.0556
p.P895S	DO222407	MELA	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.1111
p.P202F	DO222562	MELA	ICGC	DSGTGLT	DEG_SCF_TRCP1_1	207:213	Mutation rewiring degron network	0.1944
p.G846E	DO33043	PACA	ICGC	PKENL	DEG_APCC_KENBOX_2	837:841	Mutation rewiring degron network	0.1944
p.P845H	DO47578	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	837:841	Mutation rewiring degron network	0.2222
p.R836H	DO231363	THCA	ICGC	PKENL	DEG_APCC_KENBOX_2	837:841	Mutation blocking phosphorylation signal	0.75
p.K841R	DO42033	UCEC	ICGC	PKENL	DEG_APCC_KENBOX_2	837:841	Mutation altering degron motif	0.7237
p.A206T	DO223282	UCEC	ICGC	DSGTGLT	DEG_SCF_TRCP1_1	207:213	Mutation rewiring degron network	0.3056
p.F715L	DO223286	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation blocking phosphorylation signal	0.5556
p.T890N	DO41578	UCEC	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.25
p.V732A	DO42568	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation rewiring degron network	0.1944
p.T890I	DO42568	UCEC	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.25
p.P894L	SIDM00683	Prostate Carcinoma	GDSC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation blocking ubiquitination signal	0.5833
p.P894L	ACH-000977	lymph node	CCLE	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation blocking ubiquitination signal	0.5833
p.T893M	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.1667
p.T893M	NCI-H1651	lung	COSMIC	PRKQLQFLP	DEG_APCC_DBOX_1	879:887	Mutation rewiring degron network	0.1667
p.E721Q	SIDM01100	Neuroblastoma	GDSC	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation blocking phosphorylation signal	0.7222
p.E721Q	ACH-000366	Neuroblastoma	CCLE	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation blocking phosphorylation signal	0.7222
p.E721Q	SK-N-DZ	autonomic ganglia	COSMIC	PGSSS	DEG_SPOP_SBC_1	723:727	Mutation blocking phosphorylation signal	0.7222
p.R829Q	SIDM00807	Bladder Carcinoma	GDSC	PKENL	DEG_APCC_KENBOX_2	837:841	Mutation rewiring degron network	0.1111
p.G200D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DSGTGLT	DEG_SCF_TRCP1_1	207:213	Mutation rewiring degron network	0.1389
p.G200D	ACH-001127	Leukemia	CCLE	DSGTGLT	DEG_SCF_TRCP1_1	207:213	Mutation rewiring degron network	0.1389
p.G200D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DSGTGLT	DEG_SCF_TRCP1_1	207:213	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MPHOSPH9

UniProt ID: Q99550

Entrez ID: 10198

Protein name: M-phase phosphoprotein 9

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MPHOSPH9 in