DegronMD

Uniprot ID: Q99550

Source protein: M-phase phosphoprotein 9

Source gene: MPHOSPH9

Class: DEG_APCC_DBOX_1

Location: 879:887

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8944

ASA_SCORE: 91.1

COIL: 0.6102

CONS_SCORE: 0.4979

DSS_SCORE: 0.5333

HELIX: 0.3104

FCONS_SCORE: 1.473

RIG_SCORE: 0.7759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P887S	TCGA-21-1079	LUSC	TCGA	PRKQLQFLP	DEG_APCC_DBOX_1	0.5641
p.R876H	TCGA-2W-A8YY	CESC	TCGA	PRKQLQFLP	DEG_APCC_DBOX_1	0.25
p.V869I	TCGA-EO-A3AU	UCEC	TCGA	PRKQLQFLP	DEG_APCC_DBOX_1	0.0556
p.V869F	TCGA-L9-A7SV	LUAD	TCGA	PRKQLQFLP	DEG_APCC_DBOX_1	0.0556
p.L872V	DO44569	LGG	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	0.1389
p.D889E	DO229045	LICA	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	0.2778
p.Q897H	DO45475	LUSC	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	0.0556
p.Q897H	DO219773	UCEC	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	0.0556
p.Q897H	DO42793	UCEC	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	0.0556
p.P895S	DO222407	MELA	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	0.1111
p.T890N	DO41578	UCEC	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	0.25
p.T890I	DO42568	UCEC	ICGC	PRKQLQFLP	DEG_APCC_DBOX_1	0.25
p.P894L	SIDM00683	Prostate Carcinoma	GDSC	PRKQLQFLP	DEG_APCC_DBOX_1	0.5833
p.P894L	ACH-000977	lymph_node	CCLE	PRKQLQFLP	DEG_APCC_DBOX_1	0.5833
p.T893M	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PRKQLQFLP	DEG_APCC_DBOX_1	0.1667
p.T893M	NCI-H1651	lung	COSMIC	PRKQLQFLP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99550	M-phase phosphoprotein 9	DEG_APCC_DBOX_1	879:887	PRKQLQFLP	APC,CDC20,FZR1	0.8944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons