DegronMD

Uniprot ID: Q99550

Source protein: M-phase phosphoprotein 9

Source gene: MPHOSPH9

Class: DEG_SCF_TRCP1_1

Location: 207:213

E3 ligase: BTRC

DEGRON score: 0.6948

ASA_SCORE: 64.3857

COIL: 0.7541

CONS_SCORE: 0.5643

DSS_SCORE: 0.3269

HELIX: 0.1659

FCONS_SCORE: 0.9898

RIG_SCORE: 0.7088

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E219K	TCGA-4Z-AA81	BLCA	TCGA	DSGTGLT	DEG_SCF_TRCP1_1	0.1667
p.D221V	TCGA-BR-8487	STAD	TCGA	DSGTGLT	DEG_SCF_TRCP1_1	0.1111
p.E216Q	DO223599	BLCA	ICGC	DSGTGLT	DEG_SCF_TRCP1_1	0.3611
p.P202F	DO222562	MELA	ICGC	DSGTGLT	DEG_SCF_TRCP1_1	0.1944
p.A206T	DO223282	UCEC	ICGC	DSGTGLT	DEG_SCF_TRCP1_1	0.3056
p.G200D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DSGTGLT	DEG_SCF_TRCP1_1	0.1389
p.G200D	ACH-001127	Leukemia	CCLE	DSGTGLT	DEG_SCF_TRCP1_1	0.1389
p.G200D	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGTGLT	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99550	M-phase phosphoprotein 9	DEG_SCF_TRCP1_1	207:213	DSGTGLT	BTRC	0.6948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons