DegronMD

Uniprot ID: Q99550

Source protein: M-phase phosphoprotein 9

Source gene: MPHOSPH9

Class: DEG_APCC_KENBOX_2

Location: 837:841

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9987

ASA_SCORE: 97.9

COIL: 0.8

CONS_SCORE: 0.5955

DSS_SCORE: 0.4694

HELIX: 0.1666

FCONS_SCORE: 1.147

RIG_SCORE: 0.6355

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S836P	TCGA-AP-A054	UCEC	TCGA	PKENL	DEG_APCC_KENBOX_2	0.75
p.S832T	TCGA-DM-A1D8	COAD	TCGA	PKENL	DEG_APCC_KENBOX_2	0.6389
p.G846E	DO33043	PACA	ICGC	PKENL	DEG_APCC_KENBOX_2	0.1944
p.P845H	DO47578	SKCM	ICGC	PKENL	DEG_APCC_KENBOX_2	0.2222
p.R836H	DO231363	THCA	ICGC	PKENL	DEG_APCC_KENBOX_2	0.75
p.K841R	DO42033	UCEC	ICGC	PKENL	DEG_APCC_KENBOX_2	0.7237
p.R829Q	SIDM00807	Bladder Carcinoma	GDSC	PKENL	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94856	Neurofascin	DEG_APCC_KENBOX_2	143:147	PKENL	APC,CDC20,FZR1	0.9786	More...
Q13127	RE1-silencing transcription factor	DEG_APCC_KENBOX_2	868:872	PKENL	APC,CDC20,FZR1	0.7388	More...
Q99550	M-phase phosphoprotein 9	DEG_APCC_KENBOX_2	837:841	PKENL	APC,CDC20,FZR1	0.9987	More...
Q9BYD2	39S ribosomal protein L9, mitochondrial	DEG_APCC_KENBOX_2	90:94	PKENL	APC,CDC20,FZR1	0.9892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons