DegronMD

Uniprot ID: O94856

Source protein: Neurofascin

Source gene: NFASC

Class: DEG_APCC_DBOX_1

Location: 435:443

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6327

ASA_SCORE: 71.3111

COIL: 0.4688

CONS_SCORE: 0.357

DSS_SCORE: 0.0812

HELIX: 0.0177

FCONS_SCORE: 0.7502

RIG_SCORE: 0.8947

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q438H	TCGA-33-4566	LUSC	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	0.647
p.R449Q	TCGA-AA-3866	COAD	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	0.1667
p.Q438K	TCGA-AG-3731	READ	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	0.5833
p.R449W	TCGA-BR-8382	STAD	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	0.1667
p.R449W	TCGA-CM-5341	COAD	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	0.1667
p.L444I	TCGA-EI-6917	READ	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.L444I	TCGA-EO-A22X	UCEC	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.L444I	DO36881	READ	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.L444I	DO43907	UCEC	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.L444I	SIDM00650	Small Cell Lung Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.L444I	SIDM01681	Non-Cancerous	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.L444I	ACH-002362	Non-Cancerous	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.R436Q	TCGA-NH-A50T	COAD	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	0.7329
p.R436Q	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.7329
p.R436Q	ACH-000444	Lung Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	0.7329
p.R436Q	LU-99A	lung	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.7329
p.P435H	TCGA-NJ-A4YQ	LUAD	TCGA	PRNQLIRVI	DEG_APCC_DBOX_1	0.6583
p.R447Q	DO44086	COAD	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	0.2222
p.R447Q	SIDM00945	Colorectal Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.2222
p.R447Q	ACH-000895	Colon/Colorectal Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	0.2222
p.R447Q	LU-99A	lung	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.2222
p.R447Q	CL-34	large_intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.2222
p.D438G	DO222860	COCA	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	0.7198
p.T448M	DO229052	LICA	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	0.1944
p.D427Y	DO229006	LICA	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	0.1111
p.P429H	DO218944	LUAD	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	0.1667
p.S445L	DO231191	LUSC	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	0.7222
p.Q449H	DO26790	LUSC	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	0.1667
p.Q449K	DO36463	READ	ICGC	PRNQLIRVI	DEG_APCC_DBOX_1	0.1667
p.R447W	SIDM02041	Colorectal Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.2222
p.V425L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.0556
p.V425L	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.0556
p.V425L	ACH-000995	Leukemia	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	0.0556
p.V425L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.0556
p.S434A	SIDM00781	Colorectal Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.S434A	SIDM00780	Colorectal Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.S434A	ACH-000967	Colon/Colorectal Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.S434A	ACH-001199	Colon/Colorectal Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.S434A	SNU-C2B	large_intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.3056
p.R436L	SIDM01169	Ovarian Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.8428
p.R436L	ACH-000885	Ovarian Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	0.8428
p.R436L	TOV-21G	ovary	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.8428
p.R431Q	SIDM00603	Head and Neck Carcinoma	GDSC	PRNQLIRVI	DEG_APCC_DBOX_1	0.2222
p.R431Q	ACH-001543	Head and Neck Cancer	CCLE	PRNQLIRVI	DEG_APCC_DBOX_1	0.2222
p.R431Q	KOSC-2	upper_aerodigestive_tract	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.2222
p.S445A	SNU-C2B	large_intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.7222
p.R430Q	LU-99A	lung	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.1944
p.R425Q	KOSC-2	upper_aerodigestive_tract	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.0556
p.R442Q	KOSC-2	upper_aerodigestive_tract	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.7329
p.V436L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.6765
p.R447L	TOV-21G	ovary	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.2222
p.A432T	HT-115	large_intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.25
p.R430L	TOV-21G	ovary	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.1944
p.S428A	SNU-C2B	large_intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.1389
p.R441Q	CL-34	large_intestine	COSMIC	PRNQLIRVI	DEG_APCC_DBOX_1	0.6218

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRNQLIRVI

Degron related mutations and impact score

Drug responses associated with NFASC mutations

All proteins holding degron of PRNQLIRVI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94856	Neurofascin	DEG_APCC_DBOX_1	435:443	PRNQLIRVI	APC,CDC20,FZR1	0.6327	More...