DegronMD - O95500(CLDN14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T207N	TCGA-17-Z042	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.25
p.A200S	TCGA-17-Z061	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7588
p.P193H	TCGA-55-8089	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.P193H	DO23690	LUAD	ICGC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.1389
p.A208T	TCGA-AJ-A3OK	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.A208T	DO43602	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.P214S	TCGA-AX-A1CE	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.P214S	DO42280	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0556
p.T203N	DO229009	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7055
p.R199K	DO222653	MELA	ICGC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.3056
p.A196V	SIDM00602	Gastric Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.A196V	SIDM00580	Acute Myeloid Leukemia	GDSC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.A196V	SIDM00604	Oral Cavity Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.A196V	SIDM01729	Endometrial Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.A196V	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.A196V	KON	upper aerodigestive tract	COSMIC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.A196V	IM-95	stomach	COSMIC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2222
p.P198T	SIDM00120	Prostate Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.P198T	ACH-000979	Prostate Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778
p.P198T	DU-145	prostate	COSMIC	ATTTT	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.2778

Kaplan plot for CLDN14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLDN14

UniProt ID: O95500

Entrez ID: 23562

Protein name: Claudin-14

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLDN14 in