DegronMD

Uniprot ID: O95500

Source protein: Claudin-14

Source gene: CLDN14

Class: DEG_SPOP_SBC_1

Location: 200:204

E3 ligase: SPOP

DEGRON score: 0.8725

ASA_SCORE: 88.24

COIL: 0.9362

CONS_SCORE: 0.3135

DSS_SCORE: 0.5808

HELIX: 0.0286

FCONS_SCORE: 0.7199

RIG_SCORE: 0.7011

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T207N	TCGA-17-Z042	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.25
p.A200S	TCGA-17-Z061	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.7588
p.P193H	TCGA-55-8089	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1389
p.P193H	DO23690	LUAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1389
p.A208T	TCGA-AJ-A3OK	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.2222
p.A208T	DO43602	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.P214S	TCGA-AX-A1CE	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0556
p.P214S	DO42280	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0556
p.T203N	DO229009	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.7055
p.R199K	DO222653	MELA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.A196V	SIDM00602	Gastric Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.A196V	SIDM00580	Acute Myeloid Leukemia	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.A196V	SIDM00604	Oral Cavity Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.A196V	SIDM01729	Endometrial Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.A196V	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.A196V	KON	upper_aerodigestive_tract	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.A196V	IM-95	stomach	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.P198T	SIDM00120	Prostate Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.P198T	ACH-000979	Prostate Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.2778
p.P198T	DU-145	prostate	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1536:1540	ATTTT	SPOP	0.9967	More...
O94856	Neurofascin	DEG_SPOP_SBC_1	1079:1083	ATTTT	SPOP	0.901	More...
O95500	Claudin-14	DEG_SPOP_SBC_1	200:204	ATTTT	SPOP	0.8725	More...
P05067	Amyloid-beta precursor protein	DEG_SPOP_SBC_1	273:277	ATTTT	SPOP	0.8121	More...
P16989	Y-box-binding protein 3	DEG_SPOP_SBC_1	7:11	ATTTT	SPOP	0.9812	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	830:834	ATTTT	SPOP	0.9992	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	264:268	ATTTT	SPOP	0.979	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	689:693	ATTTT	SPOP	0.8785	More...
P58401	Neurexin-2-beta	DEG_SPOP_SBC_1	327:331	ATTTT	SPOP	0.9847	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	614:618	ATTTT	SPOP	0.9958	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	43:47	ATTTT	SPOP	0.8865	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	1509:1513	ATTTT	SPOP	0.9091	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	160:164	ATTTT	SPOP	0.51	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1619:1623	ATTTT	SPOP	0.9887	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	289:293	ATTTT	SPOP	0.986	More...
Q9NXI6	E3 ubiquitin-protein ligase RNF186	DEG_SPOP_SBC_1	17:21	ATTTT	SPOP	0.7472	More...
Q9P2S2	Neurexin-2	DEG_SPOP_SBC_1	1373:1377	ATTTT	SPOP	0.9995	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1294:1298	ATTTT	SPOP	0.9994	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2393:2397	ATTTT	SPOP	0.9763	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	286:290	ATTTT	SPOP	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTTT

Degron related mutations and impact score

Drug responses associated with CLDN14 mutations

All proteins holding degron of ATTTT