DegronMD - Q9HDB5(NRXN3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I42F	TCGA-05-4418	LUAD	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1944
p.I42F	DO23814	LUAD	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1944
p.G303R	TCGA-32-2632	GBM	TCGA	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.0556
p.G303R	DO12250	GBM	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.0556
p.G479A	TCGA-37-3792	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.3056
p.G479A	DO27192	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.3056
p.N494K	TCGA-37-A5EL	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.1667
p.N494K	DO223718	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.1667
p.G288V	TCGA-43-8115	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.G288V	DO26440	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.N26K	TCGA-60-2714	LUSC	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.N26K	DO26530	LUSC	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.W289L	TCGA-6A-AB49	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.7015
p.W289L	DO52020	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.7015
p.V284E	TCGA-86-8073	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944
p.V284E	DO23624	LUAD	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944
p.R489H	TCGA-A5-A0G2	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.R489H	DO41235	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.R489H	ACH-000885	Ovarian Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.R489H	ACH-002171	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.R489H	NCI-H250	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.R489H	TOV-21G	ovary	COSMIC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.F28V	TCGA-A5-A2K5	UCEC	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1944
p.F28V	DO41379	UCEC	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1944
p.R43C	TCGA-AA-A00N	COAD	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.R43C	DO9876	COAD	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.G479C	TCGA-AX-A1CE	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.3056
p.G479C	DO42280	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.3056
p.R43H	TCGA-B5-A11E	UCEC	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.R43H	TCGA-BR-4362	STAD	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.R43H	TCGA-Z6-A9VB	ESCA	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.R43H	DO33056	PACA	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.R43H	DO51544	PACA	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.R43H	DO38336	STAD	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.R43H	DO41644	UCEC	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.N281D	TCGA-B5-A3FA	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1111
p.N281D	DO52402	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1111
p.R489C	TCGA-BF-AAP4	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.R489C	TCGA-D3-A5GL	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.R489C	DO47430	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.R489C	DO219468	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.N27D	TCGA-BR-4361	STAD	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.N27D	DO38887	STAD	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.G491E	TCGA-CD-5801	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1389
p.G491E	TCGA-ER-A19F	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1389
p.G491E	DO37679	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1389
p.G491E	DO38563	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1389
p.D41H	TCGA-E5-A4TZ	BLCA	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.2222
p.D41H	DO44055	BLCA	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.2222
p.Y483D	TCGA-EO-A22X	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation altering degron motif	0.7325
p.Y483D	DO43907	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation altering degron motif	0.7325
p.N39Y	TCGA-FR-A8YC	SKCM	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.2778
p.N39Y	DO50301	SKCM	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.2778
p.S47F	TCGA-W3-AA1V	SKCM	TCGA	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.S47F	DO51276	SKCM	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.S36C	DO1076	BRCA	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7541
p.S36F	DO2155	BRCA	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7982
p.S43F	DO223732	CESC	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1667
p.R286Q	DO230326	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.25
p.R286Q	DO41644	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.25
p.R286Q	DO41638	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.25
p.R286Q	DO41458	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.25
p.R286W	DO222884	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.25
p.R286W	DO233277	GACA	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.25
p.R286W	DO222662	MELA	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.25
p.R286W	DO41020	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.25
p.I473T	DO228112	EOPC	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1389
p.S32C	DO50452	ESAD	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.3056
p.T298A	DO234205	ESAD	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944
p.G298S	DO234173	ESAD	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944
p.L287M	DO14198	HNSC	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.2778
p.V33L	DO22608	LGG	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.6765
p.V33L	DO32297	OV	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.6765
p.W34C	DO232033	LICA	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.5889
p.G30C	DO229027	LICA	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.25
p.D474Y	DO229026	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1667
p.G288C	DO229032	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.G288C	DO46591	OV	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.V288F	DO229045	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.P23L	DO222662	MELA	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.C31W	DO232058	ORCA	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.2778
p.R291H	DO34288	PACA	ICGC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.8244
p.R477C	DO34873	PACA	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.25
p.V487A	DO227544	PACA	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.25
p.F23I	DO219371	PRAD	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.A480D	DO220279	SARC	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation altering degron motif	0.7793
p.S35N	DO38217	STAD	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7069
p.S470Y	DO41542	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.0556
p.F25L	DO42472	UCEC	ICGC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1111
p.R476H	SIDM02039	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.2222
p.F23S	SIDM00845	Burkitt's Lymphoma	GDSC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.F23S	SIDM01519	Head and Neck Carcinoma	GDSC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.F23S	Daudi	haematopoietic and lymphoid tissue	COSMIC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0556
p.S44T	SIDM01090	Colorectal Carcinoma	GDSC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.S44T	ACH-000943	Colon/Colorectal Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.S44T	RKO	large intestine	COSMIC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.W37L	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.7015
p.W26C	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.W26C	ACH-000021	Lung Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.W26C	ACH-000033	Lung Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.W26C	NCI-H1693	lung	COSMIC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1389
p.G294S	SIDM00057	Neuroblastoma	GDSC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.G294S	ACN	autonomic ganglia	COSMIC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.R292C	SIDM00251	Gastric Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.8301
p.R292C	TGBC11TKB	stomach	COSMIC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.8301
p.D281E	SIDM00290	Gastric Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1111
p.D281E	HGC-27	stomach	COSMIC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1111
p.E493K	SIDM01083	Oral Cavity Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.0833
p.E493K	SCC-15	upper aerodigestive tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.0833
p.R42H	SIDM00720	Mesothelioma	GDSC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1944
p.S36Y	SIDM01611	Endometrial Carcinoma	GDSC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.712
p.S36Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation altering degron motif	0.712
p.N40S	ACH-000360	Colon/Colorectal Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.25
p.N40S	NCI-H508	large intestine	COSMIC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.25
p.S472C	ACH-000392	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1111
p.S472C	Calu-3	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1111
p.R489P	ACH-000870	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation substituting flanking lysine	0.3056
p.D480Y	ACH-000872	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation altering degron motif	0.7325
p.D41N	ACH-000981	Leukemia	CCLE	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.2222
p.D41N	DND-41	haematopoietic and lymphoid tissue	COSMIC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.2222
p.G288S	ACH-000997	Colon/Colorectal Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.G288S	ACH-001061	Colon/Colorectal Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.G288S	HCT-15	large intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.3056
p.S470F	ACH-002309	Sarcoma	CCLE	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.0556
p.S470F	SW684	soft tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.0556
p.V24L	ACH-002394	Colon/Colorectal Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0833
p.V24L	GEO	large intestine	COSMIC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.0833
p.M284I	LCLC-103H	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944
p.E491K	SCC-15	upper aerodigestive tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1389
p.P473H	NCI-H630	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.1389
p.D42E	HGC-27	stomach	COSMIC	VWSSS	DEG_SPOP_SBC_1	33:37	Mutation rewiring degron network	0.1944
p.S488Y	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	480:484	Mutation rewiring degron network	0.2222
p.T300M	HCC2998	large intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1389
p.G292S	ACN	autonomic ganglia	COSMIC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.6993
p.R290C	TGBC11TKB	stomach	COSMIC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation altering degron motif	0.8301
p.D279E	HGC-27	stomach	COSMIC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.0556
p.T298S	CW-2	large intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	289:293	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRXN3

UniProt ID: Q9HDB5

Entrez ID: 9369

Protein name: Neurexin-3-beta (Neurexin III-beta) [Cleaved into: Neurexin-3-beta, soluble form; Neurexin-3-beta, C-terminal fragment (NRXN3-CTF)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRXN3 in