DegronMD

Uniprot ID: Q9HDB5

Source protein: Neurexin-3-beta

Source gene: NRXN3

Class: DEG_SPOP_SBC_1

Location: 33:37

E3 ligase: SPOP

DEGRON score: 0.5589

ASA_SCORE: 67.96

COIL: 0.5778

CONS_SCORE: 0.4567

DSS_SCORE: 0.1397

HELIX: 0.3236

FCONS_SCORE: 1.1854

RIG_SCORE: 0.776

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I42F	TCGA-05-4418	LUAD	TCGA	VWSSS	DEG_SPOP_SBC_1	0.1944
p.I42F	DO23814	LUAD	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1944
p.N26K	TCGA-60-2714	LUSC	TCGA	VWSSS	DEG_SPOP_SBC_1	0.1389
p.N26K	DO26530	LUSC	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1389
p.F28V	TCGA-A5-A2K5	UCEC	TCGA	VWSSS	DEG_SPOP_SBC_1	0.1944
p.F28V	DO41379	UCEC	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1944
p.R43C	TCGA-AA-A00N	COAD	TCGA	VWSSS	DEG_SPOP_SBC_1	0.1667
p.R43C	DO9876	COAD	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1667
p.R43H	TCGA-B5-A11E	UCEC	TCGA	VWSSS	DEG_SPOP_SBC_1	0.1667
p.R43H	TCGA-BR-4362	STAD	TCGA	VWSSS	DEG_SPOP_SBC_1	0.1667
p.R43H	TCGA-Z6-A9VB	ESCA	TCGA	VWSSS	DEG_SPOP_SBC_1	0.1667
p.R43H	DO33056	PACA	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1667
p.R43H	DO51544	PACA	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1667
p.R43H	DO38336	STAD	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1667
p.R43H	DO41644	UCEC	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1667
p.N27D	TCGA-BR-4361	STAD	TCGA	VWSSS	DEG_SPOP_SBC_1	0.1667
p.N27D	DO38887	STAD	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1667
p.D41H	TCGA-E5-A4TZ	BLCA	TCGA	VWSSS	DEG_SPOP_SBC_1	0.2222
p.D41H	DO44055	BLCA	ICGC	VWSSS	DEG_SPOP_SBC_1	0.2222
p.N39Y	TCGA-FR-A8YC	SKCM	TCGA	VWSSS	DEG_SPOP_SBC_1	0.2778
p.N39Y	DO50301	SKCM	ICGC	VWSSS	DEG_SPOP_SBC_1	0.2778
p.S47F	TCGA-W3-AA1V	SKCM	TCGA	VWSSS	DEG_SPOP_SBC_1	0.0556
p.S47F	DO51276	SKCM	ICGC	VWSSS	DEG_SPOP_SBC_1	0.0556
p.S36C	DO1076	BRCA	ICGC	VWSSS	DEG_SPOP_SBC_1	0.7541
p.S36F	DO2155	BRCA	ICGC	VWSSS	DEG_SPOP_SBC_1	0.7982
p.S43F	DO223732	CESC	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1667
p.S32C	DO50452	ESAD	ICGC	VWSSS	DEG_SPOP_SBC_1	0.3056
p.V33L	DO22608	LGG	ICGC	VWSSS	DEG_SPOP_SBC_1	0.6765
p.V33L	DO32297	OV	ICGC	VWSSS	DEG_SPOP_SBC_1	0.6765
p.W34C	DO232033	LICA	ICGC	VWSSS	DEG_SPOP_SBC_1	0.5889
p.G30C	DO229027	LICA	ICGC	VWSSS	DEG_SPOP_SBC_1	0.25
p.P23L	DO222662	MELA	ICGC	VWSSS	DEG_SPOP_SBC_1	0.0556
p.C31W	DO232058	ORCA	ICGC	VWSSS	DEG_SPOP_SBC_1	0.2778
p.F23I	DO219371	PRAD	ICGC	VWSSS	DEG_SPOP_SBC_1	0.0556
p.S35N	DO38217	STAD	ICGC	VWSSS	DEG_SPOP_SBC_1	0.7069
p.F25L	DO42472	UCEC	ICGC	VWSSS	DEG_SPOP_SBC_1	0.1111
p.F23S	SIDM00845	Burkitt's Lymphoma	GDSC	VWSSS	DEG_SPOP_SBC_1	0.0556
p.F23S	SIDM01519	Head and Neck Carcinoma	GDSC	VWSSS	DEG_SPOP_SBC_1	0.0556
p.F23S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VWSSS	DEG_SPOP_SBC_1	0.0556
p.S44T	SIDM01090	Colorectal Carcinoma	GDSC	VWSSS	DEG_SPOP_SBC_1	0.1389
p.S44T	ACH-000943	Colon/Colorectal Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	0.1389
p.S44T	RKO	large_intestine	COSMIC	VWSSS	DEG_SPOP_SBC_1	0.1389
p.W37L	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	VWSSS	DEG_SPOP_SBC_1	0.7015
p.W26C	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	VWSSS	DEG_SPOP_SBC_1	0.1389
p.W26C	ACH-000021	Lung Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	0.1389
p.W26C	ACH-000033	Lung Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	0.1389
p.W26C	NCI-H1693	lung	COSMIC	VWSSS	DEG_SPOP_SBC_1	0.1389
p.R42H	SIDM00720	Mesothelioma	GDSC	VWSSS	DEG_SPOP_SBC_1	0.1944
p.S36Y	SIDM01611	Endometrial Carcinoma	GDSC	VWSSS	DEG_SPOP_SBC_1	0.712
p.S36Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	0.712
p.N40S	ACH-000360	Colon/Colorectal Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	0.25
p.N40S	NCI-H508	large_intestine	COSMIC	VWSSS	DEG_SPOP_SBC_1	0.25
p.D41N	ACH-000981	Leukemia	CCLE	VWSSS	DEG_SPOP_SBC_1	0.2222
p.D41N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VWSSS	DEG_SPOP_SBC_1	0.2222
p.V24L	ACH-002394	Colon/Colorectal Cancer	CCLE	VWSSS	DEG_SPOP_SBC_1	0.0833
p.V24L	GEO	large_intestine	COSMIC	VWSSS	DEG_SPOP_SBC_1	0.0833
p.D42E	HGC-27	stomach	COSMIC	VWSSS	DEG_SPOP_SBC_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VWSSS

Degron related mutations and impact score

Drug responses associated with NRXN3 mutations

All proteins holding degron of VWSSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	33:37	VWSSS	SPOP	0.5589	More...