DegronMD

Uniprot ID: Q9HDB5

Source protein: Neurexin-3-beta

Source gene: NRXN3

Class: DEG_SPOP_SBC_1

Location: 289:293

E3 ligase: SPOP

DEGRON score: 0.986

ASA_SCORE: 89.06

COIL: 0.9336

CONS_SCORE: 0.4311

DSS_SCORE: 0.6063

HELIX: 0.0382

FCONS_SCORE: 1.0087

RIG_SCORE: 0.783

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G303R	TCGA-32-2632	GBM	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0556
p.G303R	DO12250	GBM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0556
p.G288V	TCGA-43-8115	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.3056
p.G288V	DO26440	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.W289L	TCGA-6A-AB49	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.7015
p.W289L	DO52020	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.7015
p.V284E	TCGA-86-8073	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1944
p.V284E	DO23624	LUAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.N281D	TCGA-B5-A3FA	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1111
p.N281D	DO52402	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1111
p.R286Q	DO230326	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.R286Q	DO41644	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.R286Q	DO41638	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.R286Q	DO41458	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.R286W	DO222884	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.R286W	DO233277	GACA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.R286W	DO222662	MELA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.R286W	DO41020	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.T298A	DO234205	ESAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.G298S	DO234173	ESAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.L287M	DO14198	HNSC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.G288C	DO229032	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.G288C	DO46591	OV	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.V288F	DO229045	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.R291H	DO34288	PACA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.8244
p.G294S	SIDM00057	Neuroblastoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.G294S	ACN	autonomic_ganglia	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.R292C	SIDM00251	Gastric Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.8301
p.R292C	TGBC11TKB	stomach	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.8301
p.D281E	SIDM00290	Gastric Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.1111
p.D281E	HGC-27	stomach	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.1111
p.G288S	ACH-000997	Colon/Colorectal Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.3056
p.G288S	ACH-001061	Colon/Colorectal Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.3056
p.G288S	HCT-15	large_intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.M284I	LCLC-103H	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.T300M	HCC2998	large_intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.1389
p.G292S	ACN	autonomic_ganglia	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.6993
p.R290C	TGBC11TKB	stomach	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.8301
p.D279E	HGC-27	stomach	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.0556
p.T298S	CW-2	large_intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1536:1540	ATTTT	SPOP	0.9967	More...
O94856	Neurofascin	DEG_SPOP_SBC_1	1079:1083	ATTTT	SPOP	0.901	More...
O95500	Claudin-14	DEG_SPOP_SBC_1	200:204	ATTTT	SPOP	0.8725	More...
P05067	Amyloid-beta precursor protein	DEG_SPOP_SBC_1	273:277	ATTTT	SPOP	0.8121	More...
P16989	Y-box-binding protein 3	DEG_SPOP_SBC_1	7:11	ATTTT	SPOP	0.9812	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	830:834	ATTTT	SPOP	0.9992	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	264:268	ATTTT	SPOP	0.979	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	689:693	ATTTT	SPOP	0.8785	More...
P58401	Neurexin-2-beta	DEG_SPOP_SBC_1	327:331	ATTTT	SPOP	0.9847	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	614:618	ATTTT	SPOP	0.9958	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	43:47	ATTTT	SPOP	0.8865	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	1509:1513	ATTTT	SPOP	0.9091	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	160:164	ATTTT	SPOP	0.51	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1619:1623	ATTTT	SPOP	0.9887	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	289:293	ATTTT	SPOP	0.986	More...
Q9NXI6	E3 ubiquitin-protein ligase RNF186	DEG_SPOP_SBC_1	17:21	ATTTT	SPOP	0.7472	More...
Q9P2S2	Neurexin-2	DEG_SPOP_SBC_1	1373:1377	ATTTT	SPOP	0.9995	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1294:1298	ATTTT	SPOP	0.9994	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2393:2397	ATTTT	SPOP	0.9763	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	286:290	ATTTT	SPOP	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTTT

Degron related mutations and impact score

Drug responses associated with NRXN3 mutations

All proteins holding degron of ATTTT