DegronMD

Uniprot ID: Q9H347

Source protein: Ubiquilin-3

Source gene: UBQLN3

Class: DEG_SPOP_SBC_1

Location: 286:290

E3 ligase: SPOP

DEGRON score: 0.9975

ASA_SCORE: 88.64

COIL: 0.9464

CONS_SCORE: 0.3802

DSS_SCORE: 0.6545

HELIX: 0.0358

FCONS_SCORE: 1.1128

RIG_SCORE: 0.7112

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S294L	TCGA-34-2605	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.2222
p.S294L	DO26471	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.A286T	TCGA-AD-A5EJ	COAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.7139
p.A286T	DO50090	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.7139
p.N276T	TCGA-B7-5818	STAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0556
p.N276T	DO38883	STAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0556
p.P277S	TCGA-D3-A8GI	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0833
p.P277S	DO50284	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0833
p.R295M	TCGA-EO-A22X	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1944
p.R295M	DO43907	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.D300H	TCGA-JW-A5VL	CESC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0556
p.D300H	DO49976	CESC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0556
p.P277L	TCGA-MP-A4T7	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0833
p.P277L	TCGA-W3-A824	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0833
p.P277L	DO45370	LUAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0833
p.P277L	DO51271	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.0833
p.F278V	TCGA-XF-A8HG	BLCA	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1111
p.F278V	DO49802	BLCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1111
p.T290S	DO229010	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.6005
p.T290S	DO229016	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.6005
p.T290S	DO229489	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	0.6005
p.T290S	DO52365	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.6005
p.E297Q	DO44800	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1389
p.P293L	DO222699	MELA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.25
p.N298S	DO233295	NACA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1111
p.T282A	DO233299	NACA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.N285D	SIDM00969	Ovarian Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.N285D	SIDM00319	Melanoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.N285D	SIDM00277	Acute Myeloid Leukemia	GDSC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.N285D	SIDM01229	Neuroblastoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.N285D	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.N285D	SIDM01387	Small Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.T288S	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.6005
p.T288S	HARA	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.6005
p.P293H	SIDM01182	Bladder Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.25
p.P293H	ACH-000522	Bladder Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.25
p.P293H	UM-UC-3	urinary_tract	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.25
p.T288I	SIDM00591	Oral Cavity Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.7078
p.T288I	ACH-002045	Head and Neck Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.7078
p.T288I	HO-1-u-1	upper_aerodigestive_tract	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.7078
p.D284N	ACH-002396	Bone Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.2778
p.D284N	Sarc9371	bone	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1536:1540	ATTTT	SPOP	0.9967	More...
O94856	Neurofascin	DEG_SPOP_SBC_1	1079:1083	ATTTT	SPOP	0.901	More...
O95500	Claudin-14	DEG_SPOP_SBC_1	200:204	ATTTT	SPOP	0.8725	More...
P05067	Amyloid-beta precursor protein	DEG_SPOP_SBC_1	273:277	ATTTT	SPOP	0.8121	More...
P16989	Y-box-binding protein 3	DEG_SPOP_SBC_1	7:11	ATTTT	SPOP	0.9812	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	830:834	ATTTT	SPOP	0.9992	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	264:268	ATTTT	SPOP	0.979	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	689:693	ATTTT	SPOP	0.8785	More...
P58401	Neurexin-2-beta	DEG_SPOP_SBC_1	327:331	ATTTT	SPOP	0.9847	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	614:618	ATTTT	SPOP	0.9958	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	43:47	ATTTT	SPOP	0.8865	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	1509:1513	ATTTT	SPOP	0.9091	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	160:164	ATTTT	SPOP	0.51	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1619:1623	ATTTT	SPOP	0.9887	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	289:293	ATTTT	SPOP	0.986	More...
Q9NXI6	E3 ubiquitin-protein ligase RNF186	DEG_SPOP_SBC_1	17:21	ATTTT	SPOP	0.7472	More...
Q9P2S2	Neurexin-2	DEG_SPOP_SBC_1	1373:1377	ATTTT	SPOP	0.9995	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1294:1298	ATTTT	SPOP	0.9994	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2393:2397	ATTTT	SPOP	0.9763	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	286:290	ATTTT	SPOP	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTTT

Degron related mutations and impact score

Drug responses associated with UBQLN3 mutations

All proteins holding degron of ATTTT