DegronMD - Q9NXI6(RNF186)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A25V	TCGA-BS-A0UV	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2222
p.A25V	DO42793	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2222
p.P26S	TCGA-FW-A3R5	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1944
p.P26S	DO37406	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1944
p.G28V	TCGA-G4-6302	COAD	TCGA	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1389
p.G28V	DO8778	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1389
p.A23T	DO227999	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.A23T	DO229010	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.A23T	DO229013	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.A23T	DO229016	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.A23T	DO229005	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.A23T	DO229505	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.A23T	DO50989	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.A23T	DO230937	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.A23T	DO231051	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.P26L	DO11854	GBM	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.1944
p.T22N	DO228974	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.3056
p.A17D	DO228971	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.7793
p.I13M	SIDM00311	Mesothelioma	GDSC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2222
p.I13M	H2810	pleura	COSMIC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2222
p.A15T	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778

Kaplan plot for RNF186 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNF186

UniProt ID: Q9NXI6

Entrez ID: 54546

Protein name: E3 ubiquitin-protein ligase RNF186 (EC 2.3.2.27) (RING finger protein 186)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNF186 in