DegronMD

Uniprot ID: Q9NXI6

Source protein: E3 ubiquitin-protein ligase RNF186

Source gene: RNF186

Class: DEG_SPOP_SBC_1

Location: 17:21

E3 ligase: SPOP

DEGRON score: 0.7472

ASA_SCORE: 88.38

COIL: 0.9262

CONS_SCORE: 0.5477

DSS_SCORE: 0.4657

HELIX: 0.0218

FCONS_SCORE: 1.0054

RIG_SCORE: 0.7162

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A25V	TCGA-BS-A0UV	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.2222
p.A25V	DO42793	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.P26S	TCGA-FW-A3R5	SKCM	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1944
p.P26S	DO37406	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.G28V	TCGA-G4-6302	COAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.1389
p.G28V	DO8778	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1389
p.A23T	DO227999	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.A23T	DO229010	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.A23T	DO229013	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.A23T	DO229016	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.A23T	DO229005	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.A23T	DO229505	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.A23T	DO50989	LAML	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.A23T	DO230937	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.A23T	DO231051	LUSC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.2778
p.P26L	DO11854	GBM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.T22N	DO228974	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.A17D	DO228971	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.7793
p.I13M	SIDM00311	Mesothelioma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.I13M	H2810	pleura	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.A15T	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1536:1540	ATTTT	SPOP	0.9967	More...
O94856	Neurofascin	DEG_SPOP_SBC_1	1079:1083	ATTTT	SPOP	0.901	More...
O95500	Claudin-14	DEG_SPOP_SBC_1	200:204	ATTTT	SPOP	0.8725	More...
P05067	Amyloid-beta precursor protein	DEG_SPOP_SBC_1	273:277	ATTTT	SPOP	0.8121	More...
P16989	Y-box-binding protein 3	DEG_SPOP_SBC_1	7:11	ATTTT	SPOP	0.9812	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	830:834	ATTTT	SPOP	0.9992	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	264:268	ATTTT	SPOP	0.979	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	689:693	ATTTT	SPOP	0.8785	More...
P58401	Neurexin-2-beta	DEG_SPOP_SBC_1	327:331	ATTTT	SPOP	0.9847	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	614:618	ATTTT	SPOP	0.9958	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	43:47	ATTTT	SPOP	0.8865	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	1509:1513	ATTTT	SPOP	0.9091	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	160:164	ATTTT	SPOP	0.51	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1619:1623	ATTTT	SPOP	0.9887	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	289:293	ATTTT	SPOP	0.986	More...
Q9NXI6	E3 ubiquitin-protein ligase RNF186	DEG_SPOP_SBC_1	17:21	ATTTT	SPOP	0.7472	More...
Q9P2S2	Neurexin-2	DEG_SPOP_SBC_1	1373:1377	ATTTT	SPOP	0.9995	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1294:1298	ATTTT	SPOP	0.9994	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2393:2397	ATTTT	SPOP	0.9763	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	286:290	ATTTT	SPOP	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTTT

Degron related mutations and impact score

Drug responses associated with RNF186 mutations

All proteins holding degron of ATTTT