DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
ATTTT
Uniprot ID:
Q16665
Source protein:
Hypoxia-inducible factor 1-alpha
Source gene:
HIF1A
Class:
DEG_SPOP_SBC_1
Location:
614:618
E3 ligase:
SPOP
DEGRON score:
0.9958
ASA_SCORE:
84.36
COIL:
0.9402
CONS_SCORE:
0.6876
DSS_SCORE:
0.5633
HELIX:
0.0344
FCONS_SCORE:
0.9512
RIG_SCORE:
0.7413
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q620E
TCGA-CN-4731
HNSC
TCGA
ATTTT
DEG_SPOP_SBC_1
0.2778
p.Q620E
DO15886
HNSC
ICGC
ATTTT
DEG_SPOP_SBC_1
0.2778
p.S621N
TCGA-EB-A431
SKCM
TCGA
ATTTT
DEG_SPOP_SBC_1
0.25
p.S621N
DO37671
SKCM
ICGC
ATTTT
DEG_SPOP_SBC_1
0.25
p.P614S
TCGA-V5-A7RE
ESCA
TCGA
ATTTT
DEG_SPOP_SBC_1
0.6752
p.H625D
DO6320
CESC
ICGC
ATTTT
DEG_SPOP_SBC_1
0.25
p.E622D
DO8842
COAD
ICGC
ATTTT
DEG_SPOP_SBC_1
0.2222
p.P606S
DO229013
COCA
ICGC
ATTTT
DEG_SPOP_SBC_1
0.1111
p.P606S
DO225404
LAML
ICGC
ATTTT
DEG_SPOP_SBC_1
0.1111
p.P626Q
DO47469
SKCM
ICGC
ATTTT
DEG_SPOP_SBC_1
0.1111
p.A617P
SIDM00299
Other Sarcomas
GDSC
ATTTT
DEG_SPOP_SBC_1
0.7503
p.A617P
MFH-ino
soft_tissue
COSMIC
ATTTT
DEG_SPOP_SBC_1
0.7503
p.D623E
ACH-002282
Neuroblastoma
CCLE
ATTTT
DEG_SPOP_SBC_1
0.1944
p.D623E
NB17
autonomic_ganglia
COSMIC
ATTTT
DEG_SPOP_SBC_1
0.1944
p.P626S
NCI-H1304
lung
COSMIC
ATTTT
DEG_SPOP_SBC_1
0.1111
p.I618V
NCI-H446
lung
COSMIC
ATTTT
DEG_SPOP_SBC_1
0.7076
p.K615N
HN
upper_aerodigestive_tract
COSMIC
ATTTT
DEG_SPOP_SBC_1
0.6918
p.D622E
NB17
autonomic_ganglia
COSMIC
ATTTT
DEG_SPOP_SBC_1
0.2222
Drug responses associated with HIF1A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ATTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75179
Ankyrin repeat domain-containing protein 17
DEG_SPOP_SBC_1
1536:1540
ATTTT
SPOP
0.9967
More...
O94856
Neurofascin
DEG_SPOP_SBC_1
1079:1083
ATTTT
SPOP
0.901
More...
O95500
Claudin-14
DEG_SPOP_SBC_1
200:204
ATTTT
SPOP
0.8725
More...
P05067
Amyloid-beta precursor protein
DEG_SPOP_SBC_1
273:277
ATTTT
SPOP
0.8121
More...
P16989
Y-box-binding protein 3
DEG_SPOP_SBC_1
7:11
ATTTT
SPOP
0.9812
More...
P42566
Epidermal growth factor receptor substrate 15
DEG_SPOP_SBC_1
830:834
ATTTT
SPOP
0.9992
More...
P54727
UV excision repair protein RAD23 homolog B
DEG_SPOP_SBC_1
264:268
ATTTT
SPOP
0.979
More...
P57071
PR domain zinc finger protein 15
DEG_SPOP_SBC_1
689:693
ATTTT
SPOP
0.8785
More...
P58401
Neurexin-2-beta
DEG_SPOP_SBC_1
327:331
ATTTT
SPOP
0.9847
More...
Q16665
Hypoxia-inducible factor 1-alpha
DEG_SPOP_SBC_1
614:618
ATTTT
SPOP
0.9958
More...
Q6ZVD8
PH domain leucine-rich repeat-containing protein phosphatase 2
DEG_SPOP_SBC_1
43:47
ATTTT
SPOP
0.8865
More...
Q8IWZ3
Ankyrin repeat and KH domain-containing protein 1
DEG_SPOP_SBC_1
1509:1513
ATTTT
SPOP
0.9091
More...
Q9BVL2
Nucleoporin p58/p45
DEG_SPOP_SBC_1
160:164
ATTTT
SPOP
0.51
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
1619:1623
ATTTT
SPOP
0.9887
More...
Q9HDB5
Neurexin-3-beta
DEG_SPOP_SBC_1
289:293
ATTTT
SPOP
0.986
More...
Q9NXI6
E3 ubiquitin-protein ligase RNF186
DEG_SPOP_SBC_1
17:21
ATTTT
SPOP
0.7472
More...
Q9P2S2
Neurexin-2
DEG_SPOP_SBC_1
1373:1377
ATTTT
SPOP
0.9995
More...
Q9Y4C0
Neurexin-3
DEG_SPOP_SBC_1
1294:1298
ATTTT
SPOP
0.9994
More...
Q2M2H8
Probable maltase-glucoamylase 2
DEG_SPOP_SBC_1
2393:2397
ATTTT
SPOP
0.9763
More...
Q9H347
Ubiquilin-3
DEG_SPOP_SBC_1
286:290
ATTTT
SPOP
0.9975
More...