DegronMD - P57071(PRDM15)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1449I	TCGA-AA-3864	COAD	TCGA	ITPLGS	DEG_SCF_FBW7_1	1454:1459	Mutation rewiring degron network	0.1944
p.V1276I	TCGA-B5-A1MU	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.0833
p.A1270T	TCGA-B5-A3FC	UCEC	TCGA	PETTT	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.25
p.T1455M	TCGA-BB-7870	HNSC	TCGA	ITPLGS	DEG_SCF_FBW7_1	1454:1459	Mutation altering degron motif	0.7423
p.T1358N	TCGA-BT-A20N	BLCA	TCGA	VTTPSSS	DEG_SCF_FBW7_1	1357:1363	Mutation altering degron motif	0.5944
p.P1373L	TCGA-D3-A8GM	SKCM	TCGA	VTTPSSS	DEG_SCF_FBW7_1	1357:1363	Mutation rewiring degron network	0.0556
p.S1453Y	TCGA-DU-6392	LGG	TCGA	ITPLGS	DEG_SCF_FBW7_1	1454:1459	Mutation rewiring degron network	0.3056
p.R679W	TCGA-EA-A410	CESC	TCGA	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.0556
p.R679W	TCGA-VQ-A8P2	STAD	TCGA	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.0556
p.R679W	SIDM00537	Colorectal Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.0556
p.R679W	GP5d	large intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.0556
p.H681Y	DO51734	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1111
p.R699H	DO9772	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1667
p.R699H	DO42312	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1667
p.G690D	DO222363	MELA	ICGC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation altering degron motif	0.7198
p.K689N	DO47683	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation altering degron motif	0.6918
p.R698W	DO43867	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1944
p.Y688H	DO41518	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.3056
p.A1253V	SIDM02021	Esophageal Carcinoma	GDSC	PETTT	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.0556
p.S697L	SIDM00578	Neuroblastoma	GDSC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2222
p.S697L	SIDM01471	Chronic Myelogenous Leukemia	GDSC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2222
p.S697L	SIDM01446	Glioblastoma	GDSC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2222
p.S697L	SIDM01448	Head and Neck Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.2222
p.S1362I	SIDM01039	Other Solid Cancers	GDSC	VTTPSSS	DEG_SCF_FBW7_1	1357:1363	Mutation altering degron motif	0.623
p.S1362I	JAR	placenta	COSMIC	VTTPSSS	DEG_SCF_FBW7_1	1357:1363	Mutation altering degron motif	0.623
p.D694N	SIDM00963	Breast Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.3056
p.D694N	BT-474	breast	COSMIC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.3056
p.F1444L	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	ITPLGS	DEG_SCF_FBW7_1	1454:1459	Mutation rewiring degron network	0.0556
p.F1444L	KARPAS-422	haematopoietic and lymphoid tissue	COSMIC	ITPLGS	DEG_SCF_FBW7_1	1454:1459	Mutation rewiring degron network	0.0556
p.D1257N	SIDM01525	Acute Myeloid Leukemia	GDSC	PETTT	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1667
p.D1257N	ACH-000557	Leukemia	CCLE	PETTT	DEG_SPOP_SBC_1	1263:1267	Mutation rewiring degron network	0.1667
p.T1468M	ACH-000999	Colon/Colorectal Cancer	CCLE	ITPLGS	DEG_SCF_FBW7_1	1454:1459	Mutation rewiring degron network	0.0833
p.G690V	ACH-001622	Brain Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation altering degron motif	0.7532
p.I682T	ACH-001738	Leukemia	CCLE	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation rewiring degron network	0.1389
p.C692Y	NCI-H748	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	689:693	Mutation altering degron motif	0.7087

Kaplan plot for PRDM15 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRDM15

UniProt ID: P57071

Entrez ID: 63977

Protein name: PR domain zinc finger protein 15 (EC 2.1.1.-) (PR domain-containing protein 15) (Zinc finger protein 298)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRDM15 in