DegronMD

Uniprot ID: P57071

Source protein: PR domain zinc finger protein 15

Source gene: PRDM15

Class: DEG_SPOP_SBC_1

Location: 689:693

E3 ligase: SPOP

DEGRON score: 0.8785

ASA_SCORE: 59.1

COIL: 0.463

CONS_SCORE: 0.5443

DSS_SCORE: 0.4125

HELIX: 0.0202

FCONS_SCORE: 0.7463

RIG_SCORE: 0.7319

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R679W	TCGA-EA-A410	CESC	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0556
p.R679W	TCGA-VQ-A8P2	STAD	TCGA	ATTTT	DEG_SPOP_SBC_1	0.0556
p.R679W	SIDM00537	Colorectal Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.0556
p.R679W	GP5d	large_intestine	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.0556
p.H681Y	DO51734	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1111
p.R699H	DO9772	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1667
p.R699H	DO42312	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1667
p.G690D	DO222363	MELA	ICGC	ATTTT	DEG_SPOP_SBC_1	0.7198
p.K689N	DO47683	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	0.6918
p.R698W	DO43867	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.1944
p.Y688H	DO41518	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.S697L	SIDM00578	Neuroblastoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.S697L	SIDM01471	Chronic Myelogenous Leukemia	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.S697L	SIDM01446	Glioblastoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.S697L	SIDM01448	Head and Neck Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.2222
p.D694N	SIDM00963	Breast Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.D694N	BT-474	breast	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.3056
p.G690V	ACH-001622	Brain Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	0.7532
p.I682T	ACH-001738	Leukemia	CCLE	ATTTT	DEG_SPOP_SBC_1	0.1389
p.C692Y	NCI-H748	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1536:1540	ATTTT	SPOP	0.9967	More...
O94856	Neurofascin	DEG_SPOP_SBC_1	1079:1083	ATTTT	SPOP	0.901	More...
O95500	Claudin-14	DEG_SPOP_SBC_1	200:204	ATTTT	SPOP	0.8725	More...
P05067	Amyloid-beta precursor protein	DEG_SPOP_SBC_1	273:277	ATTTT	SPOP	0.8121	More...
P16989	Y-box-binding protein 3	DEG_SPOP_SBC_1	7:11	ATTTT	SPOP	0.9812	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	830:834	ATTTT	SPOP	0.9992	More...
P54727	UV excision repair protein RAD23 homolog B	DEG_SPOP_SBC_1	264:268	ATTTT	SPOP	0.979	More...
P57071	PR domain zinc finger protein 15	DEG_SPOP_SBC_1	689:693	ATTTT	SPOP	0.8785	More...
P58401	Neurexin-2-beta	DEG_SPOP_SBC_1	327:331	ATTTT	SPOP	0.9847	More...
Q16665	Hypoxia-inducible factor 1-alpha	DEG_SPOP_SBC_1	614:618	ATTTT	SPOP	0.9958	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	43:47	ATTTT	SPOP	0.8865	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	DEG_SPOP_SBC_1	1509:1513	ATTTT	SPOP	0.9091	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	160:164	ATTTT	SPOP	0.51	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1619:1623	ATTTT	SPOP	0.9887	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	289:293	ATTTT	SPOP	0.986	More...
Q9NXI6	E3 ubiquitin-protein ligase RNF186	DEG_SPOP_SBC_1	17:21	ATTTT	SPOP	0.7472	More...
Q9P2S2	Neurexin-2	DEG_SPOP_SBC_1	1373:1377	ATTTT	SPOP	0.9995	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1294:1298	ATTTT	SPOP	0.9994	More...
Q2M2H8	Probable maltase-glucoamylase 2	DEG_SPOP_SBC_1	2393:2397	ATTTT	SPOP	0.9763	More...
Q9H347	Ubiquilin-3	DEG_SPOP_SBC_1	286:290	ATTTT	SPOP	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATTTT

Degron related mutations and impact score

Drug responses associated with PRDM15 mutations

All proteins holding degron of ATTTT