DegronMD - P58401(NRXN2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K332N	TCGA-33-4586	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.3056
p.N324K	TCGA-60-2714	LUSC	TCGA	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.25
p.R323H	TCGA-AJ-A3OJ	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.R323H	TCGA-AP-A0LM	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.L463M	TCGA-AX-A1CE	UCEC	TCGA	DDEDFYTTFP	CBL_PTK	463:472	Mutation altering degron motif	0.711
p.N338D	TCGA-B5-A3FA	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1389
p.K457N	TCGA-BF-A1PZ	SKCM	TCGA	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.1667
p.R319C	TCGA-BR-8591	STAD	TCGA	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1111
p.L468M	TCGA-CM-4743	COAD	TCGA	DDEDFYTTFP	CBL_PTK	463:472	Mutation altering degron motif	0.711
p.Q479H	TCGA-EE-A29Q	SKCM	TCGA	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.1389
p.A334T	TCGA-L5-A4OI	ESCA	TCGA	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.25
p.R467C	TCGA-LN-A49W	ESCA	TCGA	DDEDFYTTFP	CBL_PTK	463:472	Mutation altering degron motif	0.8301
p.R467C	TCGA-QG-A5Z2	COAD	TCGA	DDEDFYTTFP	CBL_PTK	463:472	Mutation altering degron motif	0.8301
p.R477H	DO219024	BLCA	ICGC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.1944
p.R477H	DO224740	PACA	ICGC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.1944
p.P476T	DO219008	BLCA	ICGC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.2222
p.A335V	DO8634	COAD	ICGC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.S330P	DO230311	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.6752
p.R477C	DO224645	COCA	ICGC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.1944
p.R454C	DO234297	ESAD	ICGC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.0833
p.L336H	DO229053	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.A459D	DO45517	LUSC	ICGC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.2222
p.R477S	DO27192	LUSC	ICGC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.1944
p.A332V	DO232761	PBCA	ICGC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.3056
p.L336F	DO50301	SKCM	ICGC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.A335T	DO47849	STAD	ICGC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.A474V	DO42312	UCEC	ICGC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.2778
p.A474V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.2778
p.E456K	DO41235	UCEC	ICGC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.1389
p.R482C	DO41235	UCEC	ICGC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.0556
p.R323C	SIDM01943	Colorectal Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.D335N	SIDM01044	Other Solid Cancers	GDSC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.D335N	ACH-000585	Lung Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.D335N	EPLC-272H	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.N338T	SIDM00878	Breast Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1389
p.N338T	ACH-000930	Breast Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1389
p.N338T	HCC1569	breast	COSMIC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1389
p.L482F	SIDM00244	Neuroblastoma	GDSC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.0556
p.L482F	ACH-002083	Neuroblastoma	CCLE	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.0556
p.L482F	NB69	autonomic ganglia	COSMIC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.0556
p.H329N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7423
p.H329N	ACH-000945	Lung Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7423
p.H329N	NCI-H650	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation altering degron motif	0.7423
p.R323L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.R323L	ACH-000951	Lung Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.R323L	NCI-H2342	lung	COSMIC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.D335H	ACH-001386	Lung Cancer	CCLE	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.2222
p.S336C	BT-474	breast	COSMIC	ATTTT	DEG_SPOP_SBC_1	327:331	Mutation rewiring degron network	0.1944
p.L475F	NB69	autonomic ganglia	COSMIC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.25
p.V482A	LIM1215	large intestine	COSMIC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.0556
p.T465N	NCI-H650	lung	COSMIC	DDEDFYTTFP	CBL_PTK	463:472	Mutation altering degron motif	0.7055
p.V458A	LIM1215	large intestine	COSMIC	DDEDFYTTFP	CBL_PTK	463:472	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NRXN2

UniProt ID: P58401

Entrez ID: 9379

Protein name: Neurexin-2-beta (Neurexin II-beta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NRXN2 in