DegronMD

Uniprot ID: P58401

Source protein: Neurexin-2-beta

Source gene: NRXN2

Class: CBL_PTK

Location: 463:472

E3 ligase: CBL

DEGRON score: 0.9783

ASA_SCORE: 79.64

COIL: 0.7574

CONS_SCORE: 0.4078

DSS_SCORE: 0.52

HELIX: 0.1138

FCONS_SCORE: 1.0475

RIG_SCORE: 0.7954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L463M	TCGA-AX-A1CE	UCEC	TCGA	DDEDFYTTFP	CBL_PTK	0.711
p.K457N	TCGA-BF-A1PZ	SKCM	TCGA	DDEDFYTTFP	CBL_PTK	0.1667
p.L468M	TCGA-CM-4743	COAD	TCGA	DDEDFYTTFP	CBL_PTK	0.711
p.Q479H	TCGA-EE-A29Q	SKCM	TCGA	DDEDFYTTFP	CBL_PTK	0.1389
p.R467C	TCGA-LN-A49W	ESCA	TCGA	DDEDFYTTFP	CBL_PTK	0.8301
p.R467C	TCGA-QG-A5Z2	COAD	TCGA	DDEDFYTTFP	CBL_PTK	0.8301
p.R477H	DO219024	BLCA	ICGC	DDEDFYTTFP	CBL_PTK	0.1944
p.R477H	DO224740	PACA	ICGC	DDEDFYTTFP	CBL_PTK	0.1944
p.P476T	DO219008	BLCA	ICGC	DDEDFYTTFP	CBL_PTK	0.2222
p.R477C	DO224645	COCA	ICGC	DDEDFYTTFP	CBL_PTK	0.1944
p.R454C	DO234297	ESAD	ICGC	DDEDFYTTFP	CBL_PTK	0.0833
p.A459D	DO45517	LUSC	ICGC	DDEDFYTTFP	CBL_PTK	0.2222
p.R477S	DO27192	LUSC	ICGC	DDEDFYTTFP	CBL_PTK	0.1944
p.A474V	DO42312	UCEC	ICGC	DDEDFYTTFP	CBL_PTK	0.2778
p.A474V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DDEDFYTTFP	CBL_PTK	0.2778
p.E456K	DO41235	UCEC	ICGC	DDEDFYTTFP	CBL_PTK	0.1389
p.R482C	DO41235	UCEC	ICGC	DDEDFYTTFP	CBL_PTK	0.0556
p.L482F	SIDM00244	Neuroblastoma	GDSC	DDEDFYTTFP	CBL_PTK	0.0556
p.L482F	ACH-002083	Neuroblastoma	CCLE	DDEDFYTTFP	CBL_PTK	0.0556
p.L482F	NB69	autonomic_ganglia	COSMIC	DDEDFYTTFP	CBL_PTK	0.0556
p.L475F	NB69	autonomic_ganglia	COSMIC	DDEDFYTTFP	CBL_PTK	0.25
p.V482A	LIM1215	large_intestine	COSMIC	DDEDFYTTFP	CBL_PTK	0.0556
p.T465N	NCI-H650	lung	COSMIC	DDEDFYTTFP	CBL_PTK	0.7055
p.V458A	LIM1215	large_intestine	COSMIC	DDEDFYTTFP	CBL_PTK	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons