DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DDEDFYTTFP
Uniprot ID:
Q9P2S2
Source protein:
Neurexin-2
Source gene:
NRXN2
Class:
CBL_PTK
Location:
1509:1518
E3 ligase:
CBL
DEGRON score:
0.9918
ASA_SCORE:
80.63
COIL:
0.7592
CONS_SCORE:
0.3432
DSS_SCORE:
0.52
HELIX:
0.0823
FCONS_SCORE:
1.1573
RIG_SCORE:
0.7954
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NRXN2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DDEDFYTTFP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P58401
Neurexin-2-beta
CBL_PTK
463:472
DDEDFYTTFP
CBL
0.9783
More...
Q9P2S2
Neurexin-2
CBL_PTK
1509:1518
DDEDFYTTFP
CBL
0.9918
More...
