DegronMD - O75179(ANKRD17)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1062P	TCGA-14-0866	GBM	TCGA	PQTPTPS	DEG_SCF_FBW7_1	1052:1058	Mutation rewiring degron network	0.2222
p.Q2498E	TCGA-22-5474	LUSC	TCGA	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation rewiring degron network	0.0833
p.S1649C	TCGA-55-7913	LUAD	TCGA	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation blocking phosphorylation signal	0.6944
p.T1985A	TCGA-60-2726	LUSC	TCGA	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation altering degron motif	0.7139
p.Q2391K	TCGA-69-7974	LUAD	TCGA	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.1111
p.G1819A	TCGA-78-7220	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.25
p.S1821L	TCGA-85-A4CL	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.3056
p.E2076K	TCGA-A5-A2K5	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.3056
p.E2076K	SIDM00333	Endometrial Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.3056
p.E2076K	ACH-000988	Endometrial/Uterine Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.3056
p.E2076K	MFE-319	endometrium	COSMIC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.3056
p.E87K	TCGA-A8-A075	BRCA	TCGA	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.3056
p.E87K	DO4185	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.3056
p.E87K	SIDM00528	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.3056
p.E87K	ACH-000934	Breast Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.3056
p.T1645A	TCGA-AA-3833	COAD	TCGA	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation altering degron motif	0.825
p.T1645A	DO9796	COAD	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation altering degron motif	0.825
p.A1065T	TCGA-AA-3977	COAD	TCGA	PQTPTPS	DEG_SCF_FBW7_1	1052:1058	Mutation rewiring degron network	0.1389
p.S1062Y	TCGA-AO-A0JC	BRCA	TCGA	PQTPTPS	DEG_SCF_FBW7_1	1052:1058	Mutation rewiring degron network	0.2222
p.S1062Y	DO5277	BRCA	ICGC	PQTPTPS	DEG_SCF_FBW7_1	1052:1058	Mutation rewiring degron network	0.2222
p.K1634E	TCGA-AP-A054	UCEC	TCGA	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation substituting flanking lysine	0.2222
p.K1634E	DO42256	UCEC	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation substituting flanking lysine	0.2222
p.V1994I	TCGA-AP-A1DH	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.0833
p.S2575N	TCGA-AP-A1DP	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	2573:2577	Mutation altering degron motif	0.7069
p.R1633H	TCGA-AX-A05Z	UCEC	TCGA	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0833
p.R1633H	DO40884	UCEC	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0833
p.R1633H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0833
p.R1633H	ACH-000938	Leukemia	CCLE	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0833
p.R1633H	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0833
p.S2327L	TCGA-B5-A11E	UCEC	TCGA	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1944
p.T1549A	TCGA-B5-A11E	UCEC	TCGA	ATTTT	DEG_SPOP_SBC_1	1536:1540	Mutation blocking phosphorylation signal	0.5278
p.T1549A	DO41644	UCEC	ICGC	ATTTT	DEG_SPOP_SBC_1	1536:1540	Mutation blocking phosphorylation signal	0.5278
p.S2373P	TCGA-BG-A0MQ	UCEC	TCGA	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation blocking phosphorylation signal	0.6667
p.A2384T	TCGA-BR-4361	STAD	TCGA	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.3056
p.Q2516R	TCGA-BS-A0UF	UCEC	TCGA	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation rewiring degron network	0.25
p.N1637S	TCGA-BS-A0UJ	UCEC	TCGA	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1944
p.N1637S	SIDM00060	Ovarian Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1944
p.R1633C	TCGA-BT-A2LA	BLCA	TCGA	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0833
p.R1633C	DO561	BLCA	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0833
p.G1963D	TCGA-CA-6717	COAD	TCGA	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1667
p.S1964Y	TCGA-CA-6718	COAD	TCGA	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1944
p.A2177P	TCGA-CN-6994	HNSC	TCGA	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.25
p.Q2161L	TCGA-CV-6933	HNSC	TCGA	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.1667
p.H2105D	TCGA-CV-7415	HNSC	TCGA	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.1111
p.H2183D	TCGA-D8-A1JA	BRCA	TCGA	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.0833
p.P2180A	TCGA-D8-A1JA	BRCA	TCGA	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.1667
p.E2501A	TCGA-DD-AADR	LIHC	TCGA	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation rewiring degron network	0.1667
p.R1995Q	TCGA-DF-A2KU	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.0556
p.L1965F	TCGA-DK-A3X2	BLCA	TCGA	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.2222
p.S2347L	TCGA-EB-A5SG	SKCM	TCGA	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.0556
p.S2347L	SIDM00158	Glioblastoma	GDSC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.0556
p.S2347L	ACH-000623	Brain Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.0556
p.H1043N	TCGA-EE-A2MM	SKCM	TCGA	PQTPTPS	DEG_SCF_FBW7_1	1052:1058	Mutation rewiring degron network	0.0833
p.K75N	TCGA-EO-A22R	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation substituting flanking lysine	0.25
p.K75N	DO42713	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation substituting flanking lysine	0.25
p.T1979M	TCGA-EO-A22U	UCEC	TCGA	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1667
p.T1979M	TCGA-EO-A22U	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.2778
p.R2091S	TCGA-EO-A22X	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.2778
p.R2502Q	TCGA-EY-A1G8	UCEC	TCGA	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation rewiring degron network	0.1944
p.S2388Y	TCGA-F5-6814	READ	TCGA	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.1944
p.A2072V	TCGA-FI-A2D0	UCEC	TCGA	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation altering degron motif	0.5825
p.D91H	TCGA-GC-A3RC	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.D91H	DO816	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.A1822V	TCGA-HU-A4H5	STAD	TCGA	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation altering degron motif	0.5825
p.I1818R	TCGA-HU-A4H5	STAD	TCGA	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.2222
p.C2166Y	TCGA-HU-A4H8	STAD	TCGA	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.3056
p.P1969S	TCGA-MN-A4N4	LUAD	TCGA	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.6752
p.T1538S	TCGA-NJ-A4YQ	LUAD	TCGA	ATTTT	DEG_SPOP_SBC_1	1536:1540	Mutation altering degron motif	0.6005
p.Q1053E	TCGA-ZJ-AAXU	CESC	TCGA	PQTPTPS	DEG_SCF_FBW7_1	1052:1058	Mutation altering degron motif	0.5633
p.R89W	DO48566	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R89W	DO43971	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.T1655A	DO44051	BLCA	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0833
p.P2183S	DO225329	BRCA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.0833
p.S2181L	DO225329	BRCA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.1389
p.S2172P	DO2937	BRCA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation altering degron motif	0.6752
p.H2070D	DO2819	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.3056
p.P2067A	DO2819	BRCA	ICGC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation blocking phosphorylation signal	0.6667
p.G1632D	DO1285	BRCA	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation blocking phosphorylation signal	0.5
p.S2335I	DO223732	CESC	ICGC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation altering degron motif	0.623
p.A1959S	DO6543	CLLE	ICGC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.0556
p.R1835C	DO7816	COAD	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.R1835H	DO8264	COAD	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.R1639W	DO8264	COAD	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation blocking phosphorylation signal	0.6944
p.R1639W	DO40884	UCEC	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation blocking phosphorylation signal	0.6944
p.R1639W	NUGC-3	stomach	COSMIC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation blocking phosphorylation signal	0.6944
p.K75R	DO230342	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation substituting flanking lysine	0.25
p.V1544A	DO227987	COCA	ICGC	ATTTT	DEG_SPOP_SBC_1	1536:1540	Mutation rewiring degron network	0.2222
p.T1974A	DO222501	COCA	ICGC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.3056
p.T1974A	DO222501	COCA	ICGC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.1389
p.S2100R	DO228627	GACA	ICGC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.25
p.V1833A	DO233791	GACA	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.1389
p.P2369L	DO10871	GBM	ICGC	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.1111
p.H1992D	DO14926	HNSC	ICGC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.1389
p.A2064P	DO15398	HNSC	ICGC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.1389
p.V1833M	DO14378	HNSC	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.1389
p.G1632V	DO220346	KICH	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation blocking phosphorylation signal	0.5
p.S75Y	DO219684	KIRP	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation substituting flanking lysine	0.25
p.G2158A	DO228377	LICA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.0833
p.P1830T	DO228948	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.2222
p.S1993Y	DO228948	LICA	ICGC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.1111
p.P2179T	DO228976	LICA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.1944
p.A2080D	DO228976	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.1944
p.A77D	DO228971	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.P1821T	DO229018	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.3056
p.D93E	DO229015	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.A1959E	DO229029	LICA	ICGC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.0556
p.A2088E	DO229022	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.1944
p.A1644E	DO229035	LICA	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation altering degron motif	0.7701
p.T1538N	DO229008	LICA	ICGC	ATTTT	DEG_SPOP_SBC_1	1536:1540	Mutation altering degron motif	0.7055
p.E2388A	DO52245	LIHC	ICGC	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.1944
p.P2179L	DO25603	LUAD	ICGC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.1944
p.S2104F	DO25426	LUAD	ICGC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.1389
p.S2172L	DO24692	LUAD	ICGC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation altering degron motif	0.7667
p.S1536C	DO223665	LUAD	ICGC	ATTTT	DEG_SPOP_SBC_1	1536:1540	Mutation altering degron motif	0.7541
p.P2075S	DO26846	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation altering degron motif	0.6752
p.Q2385E	DO26578	LUSC	ICGC	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.2778
p.Q2083L	DO223720	LUSC	ICGC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.1111
p.Q2083L	DO223720	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.0556
p.S2100G	DO219136	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.25
p.P85A	DO27136	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7503
p.S1961F	DO222868	MELA	ICGC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1111
p.P2167T	DO34905	PACA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation altering degron motif	0.7031
p.G1987W	DO35723	PBCA	ICGC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.2778
p.P2183H	DO232761	PBCA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.0833
p.P2183H	DO41020	UCEC	ICGC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.0833
p.V2092F	DO229494	SKCA	ICGC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.3056
p.H1836Y	DO37519	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation substituting flanking lysine	0.1667
p.R89L	DO37770	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.G2326V	DO37412	SKCM	ICGC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1667
p.G2326V	NB17	autonomic ganglia	COSMIC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1667
p.G2326V	NBsusSR	autonomic ganglia	COSMIC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1667
p.K1650E	DO47442	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation substituting flanking lysine	0.3333
p.L1043F	DO47491	SKCM	ICGC	PQTPTPS	DEG_SCF_FBW7_1	1052:1058	Mutation rewiring degron network	0.0833
p.R2097K	DO48626	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation altering degron motif	0.7237
p.R89Q	DO47767	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.E2388D	DO229257	THCA	ICGC	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.1944
p.K2077N	DO40884	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.2778
p.K2077N	DO41488	UCEC	ICGC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.2778
p.S75F	DO42312	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation substituting flanking lysine	0.25
p.A1824S	DO42280	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation altering degron motif	0.7588
p.R2389Q	DO43578	UCEC	ICGC	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.1667
p.N1062K	DO41542	UCEC	ICGC	PQTPTPS	DEG_SCF_FBW7_1	1052:1058	Mutation rewiring degron network	0.2222
p.S1827L	DO41799	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.3056
p.R1978S	DO43907	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1944
p.R1978S	DO43907	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.25
p.T2327M	DO42568	UCEC	ICGC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1944
p.T2327M	DO41235	UCEC	ICGC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1944
p.T2327M	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1944
p.A1959V	DO43891	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.0556
p.P1830H	DO42472	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.2222
p.P1815H	DO43995	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.1389
p.E1963K	DO41379	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1667
p.E1963K	MFE-319	endometrium	COSMIC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1667
p.M2500T	SIDM01307	Colorectal Carcinoma	GDSC	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation rewiring degron network	0.1389
p.V2071G	SIDM00845	Burkitt's Lymphoma	GDSC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation altering degron motif	0.7532
p.V2071G	SIDM00461	Acute Myeloid Leukemia	GDSC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation altering degron motif	0.7532
p.V2071G	SIDM01519	Head and Neck Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation altering degron motif	0.7532
p.T1973A	SIDM00845	Burkitt's Lymphoma	GDSC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.7139
p.T1973A	SIDM00461	Acute Myeloid Leukemia	GDSC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.7139
p.T1973A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.7139
p.T1973A	SIDM01519	Head and Neck Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.7139
p.T1973A	ACH-000786	Lymphoma	CCLE	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.7139
p.T1973A	ACH-000992	Head and Neck Cancer	CCLE	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.7139
p.T1973A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation altering degron motif	0.7139
p.S1813T	SIDM00845	Burkitt's Lymphoma	GDSC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.S1813T	SIDM00035	Thyroid Gland Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.S1813T	SIDM00461	Acute Myeloid Leukemia	GDSC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.S1813T	SIDM01519	Head and Neck Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.S1813T	ACH-000786	Lymphoma	CCLE	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.S1813T	ACH-000992	Head and Neck Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.S1813T	Daudi	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.S1813T	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.N2579K	SIDM00855	Other Sarcomas	GDSC	VSSST	DEG_SPOP_SBC_1	2573:2577	Mutation rewiring degron network	0.2778
p.N2579K	ACH-000375	Kidney Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	2573:2577	Mutation rewiring degron network	0.2778
p.N2579K	G-402	soft tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	2573:2577	Mutation rewiring degron network	0.2778
p.N2324D	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1111
p.N2324D	ACH-000444	Lung Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1111
p.N2324D	LU-99A	lung	COSMIC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1111
p.T1979A	SIDM00042	Pancreatic Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1667
p.T1979A	SIDM00042	Pancreatic Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.2778
p.T1979A	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1667
p.T1979A	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.2778
p.T1979A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1667
p.T1979A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.2778
p.T1979A	PL4	pancreas	COSMIC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1667
p.T1979A	PL4	pancreas	COSMIC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.2778
p.T1979A	NCI-H23	lung	COSMIC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.1667
p.T1979A	NCI-H23	lung	COSMIC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.2778
p.N1829K	SIDM00264	Ewing's Sarcoma	GDSC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.25
p.N1829K	ACH-002105	Bone Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.25
p.N1829K	ES4	bone	COSMIC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.25
p.G2512A	SIDM00928	Breast Carcinoma	GDSC	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation altering degron motif	0.6429
p.G2512A	CAL-85-1	breast	COSMIC	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation altering degron motif	0.6429
p.S2097I	SIDM00094	Kidney Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation altering degron motif	0.7341
p.S2097I	ACH-002199	Kidney Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation altering degron motif	0.7341
p.S2097I	SN12C	kidney	COSMIC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation altering degron motif	0.7341
p.S2106C	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.0833
p.S2106C	ACH-000662	Lung Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.0833
p.S2106C	COR-L23	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.0833
p.G2506A	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation rewiring degron network	0.3056
p.G2506A	ACH-000638	Lung Cancer	CCLE	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation rewiring degron network	0.3056
p.G2506A	NCI-H441	lung	COSMIC	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation rewiring degron network	0.3056
p.P82T	SIDM01101	Neuroblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7031
p.P82T	ACH-000260	Neuroblastoma	CCLE	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7031
p.P82T	SK-N-AS	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7031
p.M2325T	SIDM00989	Bladder Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1389
p.M2325T	BFTC-905	urinary tract	COSMIC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.1389
p.V1959M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.0556
p.V1959M	ACH-001127	Leukemia	CCLE	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.0556
p.V1959M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	1969:1973	Mutation rewiring degron network	0.0556
p.T2175S	SIDM00261	Ewing's Sarcoma	GDSC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.3056
p.T2175S	ACH-002109	Bone Cancer	CCLE	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.3056
p.T2175S	ES8	bone	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.3056
p.G1819W	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.25
p.G1819W	ACH-000888	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.25
p.G1819W	NCI-H1793	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.25
p.T2175A	SIDM01608	Endometrial Carcinoma	GDSC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.3056
p.T2175A	ACH-000990	Endometrial/Uterine Cancer	CCLE	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.3056
p.A74V	SIDM01368	Gastric Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1111
p.A74V	ACH-000255	Gastric Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1111
p.N2386D	SIDM01611	Endometrial Carcinoma	GDSC	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.25
p.N2386D	ACH-000996	Endometrial/Uterine Cancer	CCLE	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.25
p.S2081R	SIDM01611	Endometrial Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.1667
p.S2081R	ACH-000996	Endometrial/Uterine Cancer	CCLE	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.1667
p.H2338Q	ACH-000586	Lung Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.3056
p.H2338Q	NCI-H1876	lung	COSMIC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.3056
p.R2502P	ACH-001172	Brain Cancer	CCLE	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation rewiring degron network	0.1944
p.S2373Y	ACH-001864	Bile Duct Cancer	CCLE	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation blocking phosphorylation signal	0.6667
p.K2172N	ACH-002061	Leukemia	CCLE	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation altering degron motif	0.5806
p.V2518I	ACH-002680	Brain Cancer	CCLE	IVTPSGT	DEG_SCF_FBW7_1	2507:2513	Mutation rewiring degron network	0.1944
p.P1828A	HSC-2	upper aerodigestive tract	COSMIC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.2778
p.P1813S	ONS-76	central nervous system	COSMIC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation rewiring degron network	0.0833
p.T2062S	ES8	bone	COSMIC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation rewiring degron network	0.0833
p.S2159P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.1111
p.S2159P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.1111
p.S2159P	DND-41	haematopoietic and lymphoid tissue	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.1111
p.R2183C	SNU-1040	large intestine	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.0833
p.V2332I	TE-10	oesophagus	COSMIC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation altering degron motif	0.5965
p.G1047W	NCI-H2342	lung	COSMIC	PQTPTPS	DEG_SCF_FBW7_1	1052:1058	Mutation rewiring degron network	0.1944
p.S1993C	COR-L23	lung	COSMIC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.1111
p.N2073D	LU-99A	lung	COSMIC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation altering degron motif	0.6932
p.S2091N	Daudi	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.2778
p.I1990V	Daudi	haematopoietic and lymphoid tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.1944
p.I1990V	DND-41	haematopoietic and lymphoid tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.1944
p.I1990V	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation rewiring degron network	0.1944
p.N2093H	NCI-H1299	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation altering degron motif	0.7423
p.H2087Q	NCI-H1876	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.1667
p.S2165P	SNU-1040	large intestine	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	2167:2174	Mutation rewiring degron network	0.2778
p.E1825K	MFE-319	endometrium	COSMIC	APTTT	DEG_SPOP_SBC_1	1822:1826	Mutation altering degron motif	0.7022
p.A2105S	MC116	haematopoietic and lymphoid tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.1111
p.G2393A	NCI-H441	lung	COSMIC	LLTPCSS	DEG_SCF_FBW7_1	2377:2383	Mutation rewiring degron network	0.0556
p.P2106S	CS1	bone	COSMIC	PNSSS	DEG_SPOP_SBC_1	2093:2097	Mutation rewiring degron network	0.0833
p.N2328K	G-402	soft tissue	COSMIC	VTPSST	DEG_SCF_FBW7_1	2332:2337	Mutation rewiring degron network	0.2222
p.M2074T	BFTC-905	urinary tract	COSMIC	VASSS	DEG_SPOP_SBC_1	2071:2075	Mutation altering degron motif	0.7423
p.S1984I	SN12C	kidney	COSMIC	PGTST	DEG_SPOP_SBC_1	1981:1985	Mutation altering degron motif	0.7341
p.R1653C	SNU-1040	large intestine	COSMIC	VVTTT	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD17

UniProt ID: O75179

Entrez ID: 26057

Protein name: Ankyrin repeat domain-containing protein 17 (Gene trap ankyrin repeat protein) (Serologically defined breast cancer antigen NY-BR-16)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD17 in