DegronMD

Uniprot ID: O75179

Source protein: Ankyrin repeat domain-containing protein 17

Source gene: ANKRD17

Class: DEG_SPOP_SBC_1

Location: 1969:1973

E3 ligase: SPOP

DEGRON score: 0.8395

ASA_SCORE: 96.92

COIL: 0.9246

CONS_SCORE: 0.3974

DSS_SCORE: 0.6237

HELIX: 0.0144

FCONS_SCORE: 0.9359

RIG_SCORE: 0.5724

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1963D	TCGA-CA-6717	COAD	TCGA	PTTTT	DEG_SPOP_SBC_1	0.1667
p.S1964Y	TCGA-CA-6718	COAD	TCGA	PTTTT	DEG_SPOP_SBC_1	0.1944
p.L1965F	TCGA-DK-A3X2	BLCA	TCGA	PTTTT	DEG_SPOP_SBC_1	0.2222
p.T1979M	TCGA-EO-A22U	UCEC	TCGA	PTTTT	DEG_SPOP_SBC_1	0.1667
p.P1969S	TCGA-MN-A4N4	LUAD	TCGA	PTTTT	DEG_SPOP_SBC_1	0.6752
p.A1959S	DO6543	CLLE	ICGC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.T1974A	DO222501	COCA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.3056
p.A1959E	DO229029	LICA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.S1961F	DO222868	MELA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.1111
p.R1978S	DO43907	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.1944
p.A1959V	DO43891	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.E1963K	DO41379	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.E1963K	MFE-319	endometrium	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.T1973A	SIDM00845	Burkitt's Lymphoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.7139
p.T1973A	SIDM00461	Acute Myeloid Leukemia	GDSC	PTTTT	DEG_SPOP_SBC_1	0.7139
p.T1973A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTTTT	DEG_SPOP_SBC_1	0.7139
p.T1973A	SIDM01519	Head and Neck Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.7139
p.T1973A	ACH-000786	Lymphoma	CCLE	PTTTT	DEG_SPOP_SBC_1	0.7139
p.T1973A	ACH-000992	Head and Neck Cancer	CCLE	PTTTT	DEG_SPOP_SBC_1	0.7139
p.T1973A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.7139
p.T1979A	SIDM00042	Pancreatic Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.T1979A	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.T1979A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.T1979A	PL4	pancreas	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.T1979A	NCI-H23	lung	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.V1959M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.V1959M	ACH-001127	Leukemia	CCLE	PTTTT	DEG_SPOP_SBC_1	0.0556
p.V1959M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	868:872	PTTTT	SPOP	0.8591	More...
O14827	Ras-specific guanine nucleotide-releasing factor 2	DEG_SPOP_SBC_1	766:770	PTTTT	SPOP	0.952	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1969:1973	PTTTT	SPOP	0.8395	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1453:1457	PTTTT	SPOP	0.9453	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1461:1465	PTTTT	SPOP	0.9939	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	402:406	PTTTT	SPOP	0.9031	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4625:4629	PTTTT	SPOP	0.7011	More...
Q9ULP0	Protein NDRG4	DEG_SPOP_SBC_1	252:256	PTTTT	SPOP	0.5892	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	475:479	PTTTT	SPOP	0.8956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTTT

Degron related mutations and impact score

Drug responses associated with ANKRD17 mutations

All proteins holding degron of PTTTT