DegronMD

Uniprot ID: Q4ZHG4

Source protein: Fibronectin type III domain-containing protein 1

Source gene: FNDC1

Class: DEG_SPOP_SBC_1

Location: 1453:1457

E3 ligase: SPOP

DEGRON score: 0.9453

ASA_SCORE: 97.58

COIL: 0.9616

CONS_SCORE: 0.4935

DSS_SCORE: 0.8141

HELIX: 0.0112

FCONS_SCORE: 0.7759

RIG_SCORE: 0.6852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1466L	TCGA-DG-A2KK	CESC	TCGA	PTTTT	DEG_SPOP_SBC_1	0.0833
p.R1456Q	DO227990	COCA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.7329
p.R1456Q	DO42280	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.7329
p.R1456W	DO224708	COCA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.8634
p.D1458N	DO36556	READ	ICGC	PTTTT	DEG_SPOP_SBC_1	0.3056
p.T1443N	SIDM00534	Colorectal Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.T1443N	ACH-000986	Colon/Colorectal Cancer	CCLE	PTTTT	DEG_SPOP_SBC_1	0.0556
p.T1443N	HT-115	large_intestine	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	868:872	PTTTT	SPOP	0.8591	More...
O14827	Ras-specific guanine nucleotide-releasing factor 2	DEG_SPOP_SBC_1	766:770	PTTTT	SPOP	0.952	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1969:1973	PTTTT	SPOP	0.8395	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1453:1457	PTTTT	SPOP	0.9453	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1461:1465	PTTTT	SPOP	0.9939	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	402:406	PTTTT	SPOP	0.9031	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4625:4629	PTTTT	SPOP	0.7011	More...
Q9ULP0	Protein NDRG4	DEG_SPOP_SBC_1	252:256	PTTTT	SPOP	0.5892	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	475:479	PTTTT	SPOP	0.8956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons