DegronMD

Uniprot ID: Q9ULP0

Source protein: Protein NDRG4

Source gene: NDRG4

Class: DEG_SPOP_SBC_1

Location: 252:256

E3 ligase: SPOP

DEGRON score: 0.5892

ASA_SCORE: 46.22

COIL: 0.6336

CONS_SCORE: 0.6459

DSS_SCORE: 0.3309

HELIX: 0.0536

FCONS_SCORE: 0.9237

RIG_SCORE: 0.8118

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N258S	TCGA-AP-A059	UCEC	TCGA	PTTTT	DEG_SPOP_SBC_1	0.2778
p.N258S	DO41361	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.2778
p.L250M	TCGA-DI-A0WH	UCEC	TCGA	PTTTT	DEG_SPOP_SBC_1	0.2778
p.L250M	DO43843	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.2778
p.G242W	TCGA-EE-A184	SKCM	TCGA	PTTTT	DEG_SPOP_SBC_1	0.0556
p.G242W	DO47442	SKCM	ICGC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.R260L	DO229024	LICA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.2222
p.W254L	DO229036	LICA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.7015
p.D262Y	DO229036	LICA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.D262Y	SIDM01019	Acute Myeloid Leukemia	GDSC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.D262Y	SIDM01217	Other Blood Cancers	GDSC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.D262Y	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.D262Y	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.G260V	DO23690	LUAD	ICGC	PTTTT	DEG_SPOP_SBC_1	0.2222
p.S266C	ACH-000876	Breast Cancer	CCLE	PTTTT	DEG_SPOP_SBC_1	0.0556
p.P260S	LS-411N	large_intestine	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.2222
p.T256M	HTC-C3	thyroid	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.7423
p.T256M	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.7423
p.T256M	KYSE-70	oesophagus	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.7423
p.T254M	HTC-C3	thyroid	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.7423
p.T254M	KYSE-70	oesophagus	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.7423
p.T254M	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.7423
p.T242M	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.T242M	HTC-C3	thyroid	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.T242M	KYSE-70	oesophagus	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.R244C	TGBC11TKB	stomach	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.1111
p.D242Y	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.D242Y	MY-M12	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.R256C	TGBC11TKB	stomach	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.8301
p.T253P	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.7031
p.R258C	TGBC11TKB	stomach	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.2778
p.T250M	HARA	lung	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.2778
p.T248M	HARA	lung	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	868:872	PTTTT	SPOP	0.8591	More...
O14827	Ras-specific guanine nucleotide-releasing factor 2	DEG_SPOP_SBC_1	766:770	PTTTT	SPOP	0.952	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1969:1973	PTTTT	SPOP	0.8395	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1453:1457	PTTTT	SPOP	0.9453	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1461:1465	PTTTT	SPOP	0.9939	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	402:406	PTTTT	SPOP	0.9031	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4625:4629	PTTTT	SPOP	0.7011	More...
Q9ULP0	Protein NDRG4	DEG_SPOP_SBC_1	252:256	PTTTT	SPOP	0.5892	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	475:479	PTTTT	SPOP	0.8956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTTT

Degron related mutations and impact score

Drug responses associated with NDRG4 mutations

All proteins holding degron of PTTTT