DegronMD

Uniprot ID: O14827

Source protein: Ras-specific guanine nucleotide-releasing factor 2

Source gene: RASGRF2

Class: DEG_SPOP_SBC_1

Location: 766:770

E3 ligase: SPOP

DEGRON score: 0.952

ASA_SCORE: 98.4

COIL: 0.9594

CONS_SCORE: 0.3059

DSS_SCORE: 0.7511

HELIX: 0.0222

FCONS_SCORE: 0.8734

RIG_SCORE: 0.5953

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A775V	TCGA-2Y-A9H3	LIHC	TCGA	PTTTT	DEG_SPOP_SBC_1	0.1944
p.A775V	DO219525	LIHC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.1944
p.A775V	SIDM01145	Gastric Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.1944
p.A775V	SIDM00383	Gastric Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.1944
p.A775V	SIDM00164	Biliary Tract Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.1944
p.S764N	TCGA-AX-A1C5	UCEC	TCGA	PTTTT	DEG_SPOP_SBC_1	0.2778
p.S764N	DO41422	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.2778
p.S776A	TCGA-AY-6197	COAD	TCGA	PTTTT	DEG_SPOP_SBC_1	0.6111
p.S776A	DO9956	COAD	ICGC	PTTTT	DEG_SPOP_SBC_1	0.6111
p.S763A	TCGA-B5-A1MR	UCEC	TCGA	PTTTT	DEG_SPOP_SBC_1	0.25
p.S763A	DO41758	UCEC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.25
p.D759A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PTTTT	DEG_SPOP_SBC_1	0.1389
p.D759A	ACH-002256	Leukemia	CCLE	PTTTT	DEG_SPOP_SBC_1	0.1389
p.D759A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	868:872	PTTTT	SPOP	0.8591	More...
O14827	Ras-specific guanine nucleotide-releasing factor 2	DEG_SPOP_SBC_1	766:770	PTTTT	SPOP	0.952	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1969:1973	PTTTT	SPOP	0.8395	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1453:1457	PTTTT	SPOP	0.9453	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1461:1465	PTTTT	SPOP	0.9939	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	402:406	PTTTT	SPOP	0.9031	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4625:4629	PTTTT	SPOP	0.7011	More...
Q9ULP0	Protein NDRG4	DEG_SPOP_SBC_1	252:256	PTTTT	SPOP	0.5892	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	475:479	PTTTT	SPOP	0.8956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons