DegronMD

Uniprot ID: A8CG34

Source protein: Nuclear envelope pore membrane protein POM 121C

Source gene: POM121C

Class: DEG_SPOP_SBC_1

Location: 868:872

E3 ligase: SPOP

DEGRON score: 0.8591

ASA_SCORE: 85.66

COIL: 0.8826

CONS_SCORE: 0.4755

DSS_SCORE: 0.4306

HELIX: 0.0222

FCONS_SCORE: 0.7159

RIG_SCORE: 0.7493

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T882A	TCGA-CD-A48C	STAD	TCGA	PTTTT	DEG_SPOP_SBC_1	0.0556
p.S872R	TCGA-CD-A4MG	STAD	TCGA	PTTTT	DEG_SPOP_SBC_1	0.7427
p.P880T	TCGA-CV-7091	HNSC	TCGA	PTTTT	DEG_SPOP_SBC_1	0.1111
p.T862I	TCGA-EE-A20H	SKCM	TCGA	PTTTT	DEG_SPOP_SBC_1	0.1667
p.I858V	DO228941	LICA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.S874G	SIDM01045	Endometrial Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.2778
p.S874G	EN	endometrium	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.2778
p.A864V	ES8	bone	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.2222
p.S866G	MFE-319	endometrium	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	868:872	PTTTT	SPOP	0.8591	More...
O14827	Ras-specific guanine nucleotide-releasing factor 2	DEG_SPOP_SBC_1	766:770	PTTTT	SPOP	0.952	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1969:1973	PTTTT	SPOP	0.8395	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1453:1457	PTTTT	SPOP	0.9453	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1461:1465	PTTTT	SPOP	0.9939	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	402:406	PTTTT	SPOP	0.9031	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4625:4629	PTTTT	SPOP	0.7011	More...
Q9ULP0	Protein NDRG4	DEG_SPOP_SBC_1	252:256	PTTTT	SPOP	0.5892	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	475:479	PTTTT	SPOP	0.8956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons