DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 4625:4629

E3 ligase: SPOP

DEGRON score: 0.7011

ASA_SCORE: 101.58

COIL: 0.9696

CONS_SCORE: 0.3101

DSS_SCORE: 0.6132

HELIX: 0.0082

FCONS_SCORE: -0.0017

RIG_SCORE: 0.6936

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4624I	TCGA-E5-A4U1	BLCA	TCGA	PTTTT	DEG_SPOP_SBC_1	0.3056
p.S4633C	TCGA-NC-A5HF	LUSC	TCGA	PTTTT	DEG_SPOP_SBC_1	0.2222
p.T4627I	DO44061	BLCA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.7078
p.T4630I	DO234286	ESAD	ICGC	PTTTT	DEG_SPOP_SBC_1	0.3056
p.S4636R	DO229052	LICA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.1389
p.T4617K	DO231186	LUSC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.1111
p.S4636C	DO219185	LUSC	ICGC	PTTTT	DEG_SPOP_SBC_1	0.1389
p.T4624R	DO51953	PRAD	ICGC	PTTTT	DEG_SPOP_SBC_1	0.3056
p.P4628H	DO229227	THCA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.7694
p.P4615L	SIDM00857	Melanoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.P4615L	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.0556
p.P4615L	T47D	breast	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	868:872	PTTTT	SPOP	0.8591	More...
O14827	Ras-specific guanine nucleotide-releasing factor 2	DEG_SPOP_SBC_1	766:770	PTTTT	SPOP	0.952	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1969:1973	PTTTT	SPOP	0.8395	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1453:1457	PTTTT	SPOP	0.9453	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1461:1465	PTTTT	SPOP	0.9939	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	402:406	PTTTT	SPOP	0.9031	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4625:4629	PTTTT	SPOP	0.7011	More...
Q9ULP0	Protein NDRG4	DEG_SPOP_SBC_1	252:256	PTTTT	SPOP	0.5892	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	475:479	PTTTT	SPOP	0.8956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons