DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PTTTT
Uniprot ID:
A6NF01
Source protein:
Putative nuclear envelope pore membrane protein POM 121B
Source gene:
POM121B
Class:
DEG_SPOP_SBC_1
Location:
475:479
E3 ligase:
SPOP
DEGRON score:
0.8956
ASA_SCORE:
85.3
COIL:
0.8534
CONS_SCORE:
0.2476
DSS_SCORE:
0.4306
HELIX:
0.0236
FCONS_SCORE:
0.6425
RIG_SCORE:
0.7493
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with POM121B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A8CG34
Nuclear envelope pore membrane protein POM 121C
DEG_SPOP_SBC_1
868:872
PTTTT
SPOP
0.8591
More...
O14827
Ras-specific guanine nucleotide-releasing factor 2
DEG_SPOP_SBC_1
766:770
PTTTT
SPOP
0.952
More...
O75179
Ankyrin repeat domain-containing protein 17
DEG_SPOP_SBC_1
1969:1973
PTTTT
SPOP
0.8395
More...
Q4ZHG4
Fibronectin type III domain-containing protein 1
DEG_SPOP_SBC_1
1453:1457
PTTTT
SPOP
0.9453
More...
Q4ZHG4
Fibronectin type III domain-containing protein 1
DEG_SPOP_SBC_1
1461:1465
PTTTT
SPOP
0.9939
More...
Q5T6F2
Ubiquitin-associated protein 2
DEG_SPOP_SBC_1
402:406
PTTTT
SPOP
0.9031
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
4625:4629
PTTTT
SPOP
0.7011
More...
Q9ULP0
Protein NDRG4
DEG_SPOP_SBC_1
252:256
PTTTT
SPOP
0.5892
More...
A6NF01
Putative nuclear envelope pore membrane protein POM 121B
DEG_SPOP_SBC_1
475:479
PTTTT
SPOP
0.8956
More...