DegronMD

Uniprot ID: Q5T6F2

Source protein: Ubiquitin-associated protein 2

Source gene: UBAP2

Class: DEG_SPOP_SBC_1

Location: 402:406

E3 ligase: SPOP

DEGRON score: 0.9031

ASA_SCORE: 87.2

COIL: 0.9276

CONS_SCORE: 0.3713

DSS_SCORE: 0.6769

HELIX: 0.0488

FCONS_SCORE: 0.8413

RIG_SCORE: 0.6599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T394A	DO233831	GACA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.1111
p.Q396K	DO229045	LICA	ICGC	PTTTT	DEG_SPOP_SBC_1	0.1667
p.T414A	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	PTTTT	DEG_SPOP_SBC_1	0.1111
p.T414A	ACH-000015	Lung Cancer	CCLE	PTTTT	DEG_SPOP_SBC_1	0.1111
p.T414A	NCI-H1581	lung	COSMIC	PTTTT	DEG_SPOP_SBC_1	0.1111
p.S407T	ACH-000279	Bone Cancer	CCLE	PTTTT	DEG_SPOP_SBC_1	0.3056
p.S398N	ACH-001295	Eye Cancer	CCLE	PTTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	868:872	PTTTT	SPOP	0.8591	More...
O14827	Ras-specific guanine nucleotide-releasing factor 2	DEG_SPOP_SBC_1	766:770	PTTTT	SPOP	0.952	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1969:1973	PTTTT	SPOP	0.8395	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1453:1457	PTTTT	SPOP	0.9453	More...
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1461:1465	PTTTT	SPOP	0.9939	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	402:406	PTTTT	SPOP	0.9031	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4625:4629	PTTTT	SPOP	0.7011	More...
Q9ULP0	Protein NDRG4	DEG_SPOP_SBC_1	252:256	PTTTT	SPOP	0.5892	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	475:479	PTTTT	SPOP	0.8956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons