DegronMD

Uniprot ID: O75179

Source protein: Ankyrin repeat domain-containing protein 17

Source gene: ANKRD17

Class: DEG_SCF_FBW7_1

Location: 1052:1058

E3 ligase: FBXW7

DEGRON score: 0.6825

ASA_SCORE: 44.6

COIL: 0.7231

CONS_SCORE: 0.4348

DSS_SCORE: 0.5949

HELIX: 0.2207

FCONS_SCORE: 1.0137

RIG_SCORE: 0.6116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1062P	TCGA-14-0866	GBM	TCGA	PQTPTPS	DEG_SCF_FBW7_1	0.2222
p.A1065T	TCGA-AA-3977	COAD	TCGA	PQTPTPS	DEG_SCF_FBW7_1	0.1389
p.S1062Y	TCGA-AO-A0JC	BRCA	TCGA	PQTPTPS	DEG_SCF_FBW7_1	0.2222
p.S1062Y	DO5277	BRCA	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.2222
p.H1043N	TCGA-EE-A2MM	SKCM	TCGA	PQTPTPS	DEG_SCF_FBW7_1	0.0833
p.Q1053E	TCGA-ZJ-AAXU	CESC	TCGA	PQTPTPS	DEG_SCF_FBW7_1	0.5633
p.L1043F	DO47491	SKCM	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.0833
p.N1062K	DO41542	UCEC	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.2222
p.G1047W	NCI-H2342	lung	COSMIC	PQTPTPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SCF_FBW7_1	1052:1058	PQTPTPS	FBXW7	0.6825	More...
Q8NBB4	Zinc finger and SCAN domain-containing protein 1	DEG_SCF_FBW7_1	14:20	PQTPTPS	FBXW7	0.8395	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons