DegronMD

Uniprot ID: Q8NBB4

Source protein: Zinc finger and SCAN domain-containing protein 1

Source gene: ZSCAN1

Class: DEG_SCF_FBW7_1

Location: 14:20

E3 ligase: FBXW7

DEGRON score: 0.8395

ASA_SCORE: 93.2143

COIL: 0.9541

CONS_SCORE: 0.9304

DSS_SCORE: 0.9434

HELIX: 0.0254

FCONS_SCORE: 0.9346

RIG_SCORE: 0.4907

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D23Y	TCGA-05-4382	LUAD	TCGA	PQTPTPS	DEG_SCF_FBW7_1	0.25
p.D23Y	DO24900	LUAD	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.25
p.A29T	TCGA-3C-AALI	BRCA	TCGA	PQTPTPS	DEG_SCF_FBW7_1	0.0833
p.A29T	DO219589	BRCA	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.0833
p.D23N	TCGA-85-A4QR	LUSC	TCGA	PQTPTPS	DEG_SCF_FBW7_1	0.25
p.D23N	DO45523	LUSC	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.25
p.P26S	TCGA-D3-A51G	SKCM	TCGA	PQTPTPS	DEG_SCF_FBW7_1	0.1667
p.P26S	DO47700	SKCM	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.1667
p.E21D	TCGA-HF-7134	STAD	TCGA	PQTPTPS	DEG_SCF_FBW7_1	0.3056
p.E21D	DO38607	STAD	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.3056
p.A24T	DO234156	ESAD	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.2222
p.R4W	DO233941	GACA	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.0556
p.R4W	SIDM02021	Esophageal Carcinoma	GDSC	PQTPTPS	DEG_SCF_FBW7_1	0.0556
p.Q22K	DO228338	MALY	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.2778
p.Q22K	SIDM00948	Burkitt's Lymphoma	GDSC	PQTPTPS	DEG_SCF_FBW7_1	0.2778
p.Q22K	ACH-002232	Lymphoma	CCLE	PQTPTPS	DEG_SCF_FBW7_1	0.2778
p.Q22K	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PQTPTPS	DEG_SCF_FBW7_1	0.2778
p.R4G	DO46953	RECA	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.0556
p.S10Y	DO229272	THCA	ICGC	PQTPTPS	DEG_SCF_FBW7_1	0.2222
p.R4Q	SIDM00235	Kidney Carcinoma	GDSC	PQTPTPS	DEG_SCF_FBW7_1	0.0556
p.R4Q	RCC10RGB	kidney	COSMIC	PQTPTPS	DEG_SCF_FBW7_1	0.0556
p.P28S	SIDM00240	Cervical Carcinoma	GDSC	PQTPTPS	DEG_SCF_FBW7_1	0.1111
p.P28S	ACH-002180	Cervical Cancer	CCLE	PQTPTPS	DEG_SCF_FBW7_1	0.1111
p.P28S	OMC-1	cervix	COSMIC	PQTPTPS	DEG_SCF_FBW7_1	0.1111
p.R13S	ACH-001852	Bile Duct Cancer	CCLE	PQTPTPS	DEG_SCF_FBW7_1	0.3056
p.S10F	ACH-002510	Skin Cancer	CCLE	PQTPTPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SCF_FBW7_1	1052:1058	PQTPTPS	FBXW7	0.6825	More...
Q8NBB4	Zinc finger and SCAN domain-containing protein 1	DEG_SCF_FBW7_1	14:20	PQTPTPS	FBXW7	0.8395	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons