DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VVTTT
Uniprot ID:
O75179
Source protein:
Ankyrin repeat domain-containing protein 17
Source gene:
ANKRD17
Class:
DEG_SPOP_SBC_1
Location:
1642:1646
E3 ligase:
SPOP
DEGRON score:
0.908
ASA_SCORE:
87.12
COIL:
0.7988
CONS_SCORE:
0.3605
DSS_SCORE:
0.5979
HELIX:
0.036
FCONS_SCORE:
0.8625
RIG_SCORE:
0.705
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1649C
TCGA-55-7913
LUAD
TCGA
VVTTT
DEG_SPOP_SBC_1
0.6944
p.T1645A
TCGA-AA-3833
COAD
TCGA
VVTTT
DEG_SPOP_SBC_1
0.825
p.T1645A
DO9796
COAD
ICGC
VVTTT
DEG_SPOP_SBC_1
0.825
p.K1634E
TCGA-AP-A054
UCEC
TCGA
VVTTT
DEG_SPOP_SBC_1
0.2222
p.K1634E
DO42256
UCEC
ICGC
VVTTT
DEG_SPOP_SBC_1
0.2222
p.R1633H
TCGA-AX-A05Z
UCEC
TCGA
VVTTT
DEG_SPOP_SBC_1
0.0833
p.R1633H
DO40884
UCEC
ICGC
VVTTT
DEG_SPOP_SBC_1
0.0833
p.R1633H
SIDM00429
B-Lymphoblastic Leukemia
GDSC
VVTTT
DEG_SPOP_SBC_1
0.0833
p.R1633H
ACH-000938
Leukemia
CCLE
VVTTT
DEG_SPOP_SBC_1
0.0833
p.R1633H
NALM-6
haematopoietic_and_lymphoid_tissue
COSMIC
VVTTT
DEG_SPOP_SBC_1
0.0833
p.N1637S
TCGA-BS-A0UJ
UCEC
TCGA
VVTTT
DEG_SPOP_SBC_1
0.1944
p.N1637S
SIDM00060
Ovarian Carcinoma
GDSC
VVTTT
DEG_SPOP_SBC_1
0.1944
p.R1633C
TCGA-BT-A2LA
BLCA
TCGA
VVTTT
DEG_SPOP_SBC_1
0.0833
p.R1633C
DO561
BLCA
ICGC
VVTTT
DEG_SPOP_SBC_1
0.0833
p.T1655A
DO44051
BLCA
ICGC
VVTTT
DEG_SPOP_SBC_1
0.0833
p.G1632D
DO1285
BRCA
ICGC
VVTTT
DEG_SPOP_SBC_1
0.5
p.R1639W
DO8264
COAD
ICGC
VVTTT
DEG_SPOP_SBC_1
0.6944
p.R1639W
DO40884
UCEC
ICGC
VVTTT
DEG_SPOP_SBC_1
0.6944
p.R1639W
NUGC-3
stomach
COSMIC
VVTTT
DEG_SPOP_SBC_1
0.6944
p.G1632V
DO220346
KICH
ICGC
VVTTT
DEG_SPOP_SBC_1
0.5
p.A1644E
DO229035
LICA
ICGC
VVTTT
DEG_SPOP_SBC_1
0.7701
p.K1650E
DO47442
SKCM
ICGC
VVTTT
DEG_SPOP_SBC_1
0.3333
p.R1653C
SNU-1040
large_intestine
COSMIC
VVTTT
DEG_SPOP_SBC_1
0.1389
Drug responses associated with ANKRD17 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VVTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75179
Ankyrin repeat domain-containing protein 17
DEG_SPOP_SBC_1
1642:1646
VVTTT
SPOP
0.908
More...
P05187
Alkaline phosphatase, placental type
DEG_SPOP_SBC_1
167:171
VVTTT
SPOP
0.7745
More...
P09923
Intestinal-type alkaline phosphatase
DEG_SPOP_SBC_1
164:168
VVTTT
SPOP
0.7745
More...
Q9ULC0
Endomucin
DEG_SPOP_SBC_1
32:36
VVTTT
SPOP
0.977
More...