DegronMD

Uniprot ID: P09923

Source protein: Intestinal-type alkaline phosphatase

Source gene: ALPI

Class: DEG_SPOP_SBC_1

Location: 164:168

E3 ligase: SPOP

DEGRON score: 0.7745

ASA_SCORE: 29.3

COIL: 0.2324

CONS_SCORE: 0.7555

DSS_SCORE: 0.483

HELIX: 0.009

FCONS_SCORE: 1.0437

RIG_SCORE: 0.799

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K156R	TCGA-17-Z048	LUAD	TCGA	VVTTT	DEG_SPOP_SBC_1	0.2222
p.R169L	TCGA-37-3789	LUSC	TCGA	VVTTT	DEG_SPOP_SBC_1	0.3056
p.R169L	DO26743	LUSC	ICGC	VVTTT	DEG_SPOP_SBC_1	0.3056
p.Q171H	TCGA-50-5066	LUAD	TCGA	VVTTT	DEG_SPOP_SBC_1	0.25
p.Q171H	DO25040	LUAD	ICGC	VVTTT	DEG_SPOP_SBC_1	0.25
p.G177V	TCGA-56-8309	LUSC	TCGA	VVTTT	DEG_SPOP_SBC_1	0.0833
p.G177V	DO219141	LUSC	ICGC	VVTTT	DEG_SPOP_SBC_1	0.0833
p.S174L	TCGA-CV-6961	HNSC	TCGA	VVTTT	DEG_SPOP_SBC_1	0.6111
p.S174L	DO14566	HNSC	ICGC	VVTTT	DEG_SPOP_SBC_1	0.6111
p.A173G	TCGA-EB-A42Y	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	0.1944
p.A173G	DO37691	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1944
p.G163E	TCGA-EE-A29S	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	0.3056
p.G163E	DO37936	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	0.3056
p.A173T	TCGA-F1-6874	STAD	TCGA	VVTTT	DEG_SPOP_SBC_1	0.1944
p.A173T	DO38201	STAD	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1944
p.S161L	TCGA-FS-A1ZK	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	0.25
p.S161L	DO37474	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	0.25
p.R154W	TCGA-K1-A6RT	SARC	TCGA	VVTTT	DEG_SPOP_SBC_1	0.0556
p.R154W	DO220193	SARC	ICGC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.K160Q	TCGA-W3-A824	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	0.6667
p.K160Q	DO51271	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	0.6667
p.T178A	DO52453	COCA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00450	Acute Myeloid Leukemia	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00577	Neuroblastoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00411	Pancreatic Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00589	Oral Cavity Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00351	Oral Cavity Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00383	Gastric Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00214	Colorectal Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00618	Hepatocellular Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00579	Neuroblastoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM01727	Chronic Myelogenous Leukemia	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM00192	Colorectal Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM01682	Gastric Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM01617	Endometrial Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM01336	Glioblastoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM01587	Bladder Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T178A	SIDM01574	Plasma Cell Myeloma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.R169W	DO50337	ESAD	ICGC	VVTTT	DEG_SPOP_SBC_1	0.3056
p.A158S	DO229009	LICA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1667
p.G177D	SIDM01088	Endometrial Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0833
p.G177D	ACH-000965	Endometrial/Uterine Cancer	CCLE	VVTTT	DEG_SPOP_SBC_1	0.0833
p.G177D	RL95-2	endometrium	COSMIC	VVTTT	DEG_SPOP_SBC_1	0.0833
p.V162A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VVTTT	DEG_SPOP_SBC_1	0.2778
p.V162A	ACH-000937	Leukemia	CCLE	VVTTT	DEG_SPOP_SBC_1	0.2778
p.V162A	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VVTTT	DEG_SPOP_SBC_1	0.2778
p.G159E	SIDM01768	Melanoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.1944

Drug responses associated with ALPI mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Y386* (No)	GDSC	AZD5582	42.932
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Y386* (No)	GDSC	IAP_5620	206.7173
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Y386* (No)	GDSC	IAP_7638	190.7716
SIDM01194	LIHC\|liver	p.P28L (No)	GDSC	AZD5582	119.3805
SIDM01194	LIHC\|liver	p.P28L (No)	GDSC	IAP_5620	150.2682
SIDM01194	LIHC\|liver	p.P28L (No)	GDSC	IAP_7638	112.0114
SIDM01194	LIHC\|liver	p.P28L (No)	GDSC	IAP_5620	774.96
SIDM01194	LIHC\|liver	p.A314G (No)	GDSC	AZD5582	119.3805
SIDM01194	LIHC\|liver	p.A314G (No)	GDSC	IAP_5620	150.2682
SIDM01194	LIHC\|liver	p.A314G (No)	GDSC	IAP_7638	112.0114
SIDM01194	LIHC\|liver	p.A314G (No)	GDSC	IAP_5620	774.96
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G291R (No)	GDSC	IAP_5620	21.4192
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G291R (No)	GDSC	IAP_7638	13.191
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.G291R (No)	GDSC	IAP_5620	47.968
SIDM00901	UCEC\|endometrium	p.A375V (No)	GDSC	AZD5582	7.251
SIDM00901	UCEC\|endometrium	p.A375V (No)	GDSC	IAP_5620	68.7396
SIDM00901	UCEC\|endometrium	p.A375V (No)	GDSC	IAP_7638	100.7444
SIDM00901	UCEC\|endometrium	p.A375V (No)	GDSC	IAP_5620	113.64
SIDM00382	GBM\|glioma	p.L63F (No)	GDSC	AZD5582	96.8604
SIDM00382	GBM\|glioma	p.L63F (No)	GDSC	IAP_5620	33.3539
SIDM00382	GBM\|glioma	p.L63F (No)	GDSC	IAP_7638	27.4282
SIDM00242	UNCLASSIFIED\|osteosarcoma	p.E200K (No)	GDSC	AZD5582	1.1229
SIDM00242	UNCLASSIFIED\|osteosarcoma	p.E200K (No)	GDSC	IAP_5620	41.8123
SIDM00242	UNCLASSIFIED\|osteosarcoma	p.E200K (No)	GDSC	IAP_7638	9.6294
SIDM00242	UNCLASSIFIED\|osteosarcoma	p.E200K (No)	GDSC	IAP_5620	75.41
SIDM01048	MM\|lymphoid_neoplasm_other	p.D40H (No)	GDSC	AZD5582	4.3686
SIDM01048	MM\|lymphoid_neoplasm_other	p.D40H (No)	GDSC	IAP_5620	79.1765
SIDM01048	MM\|lymphoid_neoplasm_other	p.D40H (No)	GDSC	IAP_7638	81.8362
SIDM01048	MM\|lymphoid_neoplasm_other	p.D40H (No)	GDSC	IAP_5620	40.856
SIDM00142	UCEC\|endometrium	p.S409P (No)	GDSC	AZD5582	5.1481
SIDM00142	UCEC\|endometrium	p.S409P (No)	GDSC	IAP_5620	218.8705
SIDM00142	UCEC\|endometrium	p.S409P (No)	GDSC	IAP_7638	143.7854
SIDM00142	UCEC\|endometrium	p.S409P (No)	GDSC	IAP_5620	376.95
SIDM01088	UNCLASSIFIED\|endometrium	p.N138K (No)	GDSC	AZD5582	6.2647
SIDM01088	UNCLASSIFIED\|endometrium	p.N138K (No)	GDSC	IAP_5620	47.503
SIDM01088	UNCLASSIFIED\|endometrium	p.N138K (No)	GDSC	IAP_7638	69.3986
SIDM01088	UNCLASSIFIED\|endometrium	p.N138K (No)	GDSC	IAP_5620	118.32
SIDM01088	UNCLASSIFIED\|endometrium	p.Q139E (No)	GDSC	AZD5582	6.2647
SIDM01088	UNCLASSIFIED\|endometrium	p.Q139E (No)	GDSC	IAP_5620	47.503
SIDM01088	UNCLASSIFIED\|endometrium	p.Q139E (No)	GDSC	IAP_7638	69.3986
SIDM01088	UNCLASSIFIED\|endometrium	p.Q139E (No)	GDSC	IAP_5620	118.32
SIDM01088	UNCLASSIFIED\|endometrium	p.G177D (Yes)	GDSC	AZD5582	6.2647
SIDM01088	UNCLASSIFIED\|endometrium	p.G177D (Yes)	GDSC	IAP_5620	47.503
SIDM01088	UNCLASSIFIED\|endometrium	p.G177D (Yes)	GDSC	IAP_7638	69.3986
SIDM01088	UNCLASSIFIED\|endometrium	p.G177D (Yes)	GDSC	IAP_5620	118.32
SIDM00551	ESCA\|oesophagus	p.R269H (No)	GDSC	AZD5582	3.4964
SIDM00551	ESCA\|oesophagus	p.R269H (No)	GDSC	IAP_5620	69.0167
SIDM00551	ESCA\|oesophagus	p.R269H (No)	GDSC	IAP_7638	122.9524
SIDM00551	ESCA\|oesophagus	p.R269H (No)	GDSC	IAP_5620	80.086
SIDM00619	THCA\|thyroid	p.R359T (No)	GDSC	AZD5582	6.3861
SIDM00619	THCA\|thyroid	p.R359T (No)	GDSC	IAP_5620	52.4191
SIDM00619	THCA\|thyroid	p.R359T (No)	GDSC	IAP_7638	45.0041
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.P84H (No)	GDSC	AZD5582	2.9221
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.P84H (No)	GDSC	IAP_5620	66.2563
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.P84H (No)	GDSC	IAP_7638	39.5608
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.P84H (No)	GDSC	IAP_5620	166.03
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.G64E (No)	GDSC	AZD5582	15.5755
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.G64E (No)	GDSC	IAP_5620	8.4606
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.G64E (No)	GDSC	IAP_7638	45.9467
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.G64E (No)	GDSC	IAP_5620	17.964
SIDM01003	ALL\|lymphoblastic_leukemia	p.G62W (No)	GDSC	AZD5582	3.9925
SIDM01003	ALL\|lymphoblastic_leukemia	p.G62W (No)	GDSC	IAP_5620	44.4064
SIDM01003	ALL\|lymphoblastic_leukemia	p.G62W (No)	GDSC	IAP_7638	42.1
SIDM01003	ALL\|lymphoblastic_leukemia	p.G62W (No)	GDSC	IAP_5620	8.4158
SIDM00082	SKCM\|melanoma	p.N125S (No)	GDSC	AZD5582	1.7216
SIDM00082	SKCM\|melanoma	p.N125S (No)	GDSC	IAP_5620	12.8991
SIDM00082	SKCM\|melanoma	p.N125S (No)	GDSC	IAP_7638	24.2903
SIDM00082	SKCM\|melanoma	p.N125S (No)	GDSC	IAP_5620	144
SIDM00973	SKCM\|melanoma	p.G249R (No)	GDSC	AZD5582	2.4331
SIDM00973	SKCM\|melanoma	p.G249R (No)	GDSC	IAP_5620	43.0524
SIDM00973	SKCM\|melanoma	p.G249R (No)	GDSC	IAP_7638	12.2838
SIDM00973	SKCM\|melanoma	p.G249R (No)	GDSC	IAP_5620	248.85
SIDM00987	THCA\|thyroid	p.R389* (No)	GDSC	AZD5582	20.4967
SIDM00987	THCA\|thyroid	p.R389* (No)	GDSC	IAP_5620	37.78
SIDM00987	THCA\|thyroid	p.R389* (No)	GDSC	IAP_7638	49.3009
SIDM00987	THCA\|thyroid	p.R389* (No)	GDSC	IAP_5620	259.78
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A52T (No)	GDSC	AZD5582	0.2089
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A52T (No)	GDSC	IAP_5620	49.9813
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A52T (No)	GDSC	IAP_7638	24.431
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A52T (No)	GDSC	IAP_5620	414.71
SIDM00487	COREAD\|large_intestine	p.R269C (No)	GDSC	AZD5582	69.9983
SIDM00487	COREAD\|large_intestine	p.R269C (No)	GDSC	IAP_5620	102.4297
SIDM00487	COREAD\|large_intestine	p.R269C (No)	GDSC	IAP_7638	143.0237
SIDM00487	COREAD\|large_intestine	p.R269C (No)	GDSC	IAP_5620	123.58
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.E200K (No)	GDSC	AZD5582	15.325
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.E200K (No)	GDSC	IAP_5620	73.4868
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.E200K (No)	GDSC	IAP_7638	73.4868
SIDM00368	SCLC\|lung_small_cell_carcinoma	p.E200K (No)	GDSC	IAP_5620	83.615
SIDM00545	SKCM\|melanoma	p.G221E (No)	GDSC	AZD5582	7.9076
SIDM00545	SKCM\|melanoma	p.G221E (No)	GDSC	IAP_5620	57.4027
SIDM00545	SKCM\|melanoma	p.G221E (No)	GDSC	IAP_7638	48.4612
SIDM00185	SKCM\|melanoma	p.S382F (No)	GDSC	AZD5582	19.1211
SIDM00185	SKCM\|melanoma	p.S382F (No)	GDSC	IAP_5620	103.3667
SIDM00992	THCA\|thyroid	p.S211C (No)	GDSC	AZD5582	1.7385
SIDM00992	THCA\|thyroid	p.S211C (No)	GDSC	IAP_5620	21.2834
SIDM00992	THCA\|thyroid	p.S211C (No)	GDSC	IAP_7638	33.82
SIDM00992	THCA\|thyroid	p.S211C (No)	GDSC	IAP_5620	344.37
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V162A (Yes)	GDSC	AZD5582	10.8353
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V162A (Yes)	GDSC	IAP_5620	88.6911
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V162A (Yes)	GDSC	IAP_7638	88.6911
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.V162A (Yes)	GDSC	IAP_5620	24.62
SIDM00364	ALL\|lymphoblastic_leukemia	p.S404N (No)	GDSC	AZD5582	3.0762
SIDM00364	ALL\|lymphoblastic_leukemia	p.S404N (No)	GDSC	IAP_5620	59.184
SIDM00364	ALL\|lymphoblastic_leukemia	p.S404N (No)	GDSC	IAP_7638	46.9537
SIDM00364	ALL\|lymphoblastic_leukemia	p.S404N (No)	GDSC	IAP_5620	27.624
SIDM01023	LAML\|acute_myeloid_leukaemia	p.M229L (No)	GDSC	AZD5582	3.7166
SIDM01023	LAML\|acute_myeloid_leukaemia	p.M229L (No)	GDSC	IAP_5620	121.9186
SIDM01023	LAML\|acute_myeloid_leukaemia	p.M229L (No)	GDSC	IAP_7638	110.703
SIDM00286	NB\|neuroblastoma	p.G395R (No)	GDSC	AZD5582	7.831
SIDM00286	NB\|neuroblastoma	p.G395R (No)	GDSC	IAP_5620	141.7313
SIDM00286	NB\|neuroblastoma	p.G395R (No)	GDSC	IAP_7638	141.6088

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1642:1646	VVTTT	SPOP	0.908	More...
P05187	Alkaline phosphatase, placental type	DEG_SPOP_SBC_1	167:171	VVTTT	SPOP	0.7745	More...
P09923	Intestinal-type alkaline phosphatase	DEG_SPOP_SBC_1	164:168	VVTTT	SPOP	0.7745	More...
Q9ULC0	Endomucin	DEG_SPOP_SBC_1	32:36	VVTTT	SPOP	0.977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTTT

Degron related mutations and impact score

Drug responses associated with ALPI mutations

All proteins holding degron of VVTTT