DegronMD

Uniprot ID: Q9ULC0

Source protein: Endomucin

Source gene: EMCN

Class: DEG_SPOP_SBC_1

Location: 32:36

E3 ligase: SPOP

DEGRON score: 0.977

ASA_SCORE: 90.18

COIL: 0.7904

CONS_SCORE: 0.5469

DSS_SCORE: 0.3498

HELIX: 0.0162

FCONS_SCORE: 1.4728

RIG_SCORE: 0.8034

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G22C	TCGA-43-5668	LUSC	TCGA	VVTTT	DEG_SPOP_SBC_1	0.0556
p.G22C	DO26608	LUSC	ICGC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.S39Y	TCGA-AX-A2HC	UCEC	TCGA	VVTTT	DEG_SPOP_SBC_1	0.25
p.S39Y	DO41572	UCEC	ICGC	VVTTT	DEG_SPOP_SBC_1	0.25
p.P43Q	TCGA-EE-A20F	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	0.1389
p.P43Q	DO37961	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1389
p.A26V	TCGA-F5-6812	READ	TCGA	VVTTT	DEG_SPOP_SBC_1	0.1667
p.A26V	DO36423	READ	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1667
p.E46K	TCGA-QB-AA9O	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	0.0556
p.E46K	DO51267	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.N29D	DO227987	COCA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.25
p.G22D	DO222647	MELA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T35A	DO232829	NACA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.7139
p.L24V	SIDM02059	Colorectal Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.1111
p.V33I	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.5965
p.V33I	SIDM00498	Colorectal Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1642:1646	VVTTT	SPOP	0.908	More...
P05187	Alkaline phosphatase, placental type	DEG_SPOP_SBC_1	167:171	VVTTT	SPOP	0.7745	More...
P09923	Intestinal-type alkaline phosphatase	DEG_SPOP_SBC_1	164:168	VVTTT	SPOP	0.7745	More...
Q9ULC0	Endomucin	DEG_SPOP_SBC_1	32:36	VVTTT	SPOP	0.977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons