DegronMD - P09923(ALPI)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K156R	TCGA-17-Z048	LUAD	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation substituting flanking lysine	0.2222
p.R169L	TCGA-37-3789	LUSC	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.3056
p.R169L	DO26743	LUSC	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.3056
p.Q171H	TCGA-50-5066	LUAD	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.25
p.Q171H	DO25040	LUAD	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.25
p.G177V	TCGA-56-8309	LUSC	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0833
p.G177V	DO219141	LUSC	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0833
p.S174L	TCGA-CV-6961	HNSC	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation blocking phosphorylation signal	0.6111
p.S174L	DO14566	HNSC	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation blocking phosphorylation signal	0.6111
p.A173G	TCGA-EB-A42Y	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1944
p.A173G	DO37691	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1944
p.G163E	TCGA-EE-A29S	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.3056
p.G163E	DO37936	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.3056
p.A173T	TCGA-F1-6874	STAD	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1944
p.A173T	DO38201	STAD	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1944
p.S161L	TCGA-FS-A1ZK	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.25
p.S161L	DO37474	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.25
p.R154W	TCGA-K1-A6RT	SARC	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.R154W	DO220193	SARC	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.K160Q	TCGA-W3-A824	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation blocking ubiquitination signal	0.6667
p.K160Q	DO51271	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation blocking ubiquitination signal	0.6667
p.T178A	DO52453	COCA	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00450	Acute Myeloid Leukemia	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00577	Neuroblastoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00411	Pancreatic Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00589	Oral Cavity Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00351	Oral Cavity Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00383	Gastric Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00214	Colorectal Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00618	Hepatocellular Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00579	Neuroblastoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM01727	Chronic Myelogenous Leukemia	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM00192	Colorectal Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM01682	Gastric Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM01617	Endometrial Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM01336	Glioblastoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM01587	Bladder Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.T178A	SIDM01574	Plasma Cell Myeloma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0556
p.R169W	DO50337	ESAD	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.3056
p.A158S	DO229009	LICA	ICGC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1667
p.G177D	SIDM01088	Endometrial Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0833
p.G177D	ACH-000965	Endometrial/Uterine Cancer	CCLE	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0833
p.G177D	RL95-2	endometrium	COSMIC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.0833
p.V162A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2778
p.V162A	ACH-000937	Leukemia	CCLE	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2778
p.V162A	PF-382	haematopoietic and lymphoid tissue	COSMIC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2778
p.G159E	SIDM01768	Melanoma	GDSC	VVTTT	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALPI

UniProt ID: P09923

Entrez ID: 248

Protein name: Intestinal-type alkaline phosphatase (IAP) (Intestinal alkaline phosphatase) (EC 3.1.3.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALPI in