DegronMD - Q9ULC0(EMCN)

FUNCTION: Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.

GO - Biological processes (BP): hematopoietic stem cell homeostasis [GO:0061484]

GO - Molecular function (MF):

GO - Cellular component (CC): extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S247F	TCGA-EO-A3B0	UCEC	TCGA	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation altering degron motif	0.7982
p.S247F	DO219773	UCEC	ICGC	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation altering degron motif	0.7982
p.T35A	DO232829	NACA	ICGC	VVTTT	DEG_SPOP_SBC_1	32:36	Mutation altering degron motif	0.7139
p.V33I	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	32:36	Mutation altering degron motif	0.5965
p.V33I	SIDM00498	Colorectal Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	32:36	Mutation altering degron motif	0.5965
p.K244N	TCGA-BS-A0UV	UCEC	TCGA	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation substituting flanking lysine	0.3611
p.K244N	DO42793	UCEC	ICGC	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation substituting flanking lysine	0.3611
p.S254C	TCGA-49-6742	LUAD	TCGA	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation rewiring degron network	0.2778
p.S254C	DO25622	LUAD	ICGC	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation rewiring degron network	0.2778
p.T245K	DO229037	LICA	ICGC	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation rewiring degron network	0.2778
p.T245P	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation rewiring degron network	0.2778
p.T245P	ACH-000888	Lung Cancer	CCLE	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation rewiring degron network	0.2778
p.T245P	NCI-H1793	lung	COSMIC	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation rewiring degron network	0.2778
p.S39Y	TCGA-AX-A2HC	UCEC	TCGA	VVTTT	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.25
p.S39Y	DO41572	UCEC	ICGC	VVTTT	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.25
p.A255S	TCGA-B7-A5TJ	STAD	TCGA	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation rewiring degron network	0.25
p.A255S	DO222329	STAD	ICGC	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation rewiring degron network	0.25
p.N29D	DO227987	COCA	ICGC	VVTTT	DEG_SPOP_SBC_1	32:36	Mutation rewiring degron network	0.25
p.V243I	DO229010	COCA	ICGC	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation rewiring degron network	0.2222
p.V243I	DO229227	THCA	ICGC	SHESGE	DEG_Kelch_Keap1_1	247:252	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 37 entries

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Kaplan plot for EMCN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EMCN

UniProt ID: Q9ULC0

Entrez ID: 51705

Protein name: Endomucin (Endomucin-2) (Gastric cancer antigen Ga34) (Mucin-14) (MUC-14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EMCN in