DegronMD

Uniprot ID: Q9ULC0

Source protein: Endomucin

Source gene: EMCN

Class: DEG_Kelch_Keap1_1

Location: 247:252

E3 ligase: KEAP1

DEGRON score: 0.6007

ASA_SCORE: 82.1333

COIL: 0.7417

CONS_SCORE: 1

DSS_SCORE: 0.6638

HELIX: 0.1288

FCONS_SCORE: 1.0198

RIG_SCORE: 0.6185

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G257E	TCGA-3N-A9WC	SKCM	TCGA	SHESGE	DEG_Kelch_Keap1_1	0.1944
p.G257E	DO51234	SKCM	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.1944
p.S254C	TCGA-49-6742	LUAD	TCGA	SHESGE	DEG_Kelch_Keap1_1	0.2778
p.S254C	DO25622	LUAD	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.2778
p.L241I	TCGA-AX-A2HC	UCEC	TCGA	SHESGE	DEG_Kelch_Keap1_1	0.1667
p.L241I	DO41572	UCEC	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.1667
p.A255S	TCGA-B7-A5TJ	STAD	TCGA	SHESGE	DEG_Kelch_Keap1_1	0.25
p.A255S	DO222329	STAD	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.25
p.K244N	TCGA-BS-A0UV	UCEC	TCGA	SHESGE	DEG_Kelch_Keap1_1	0.3611
p.K244N	DO42793	UCEC	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.3611
p.N261D	TCGA-DB-A64S	LGG	TCGA	SHESGE	DEG_Kelch_Keap1_1	0.0833
p.N261D	DO44619	LGG	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.0833
p.S247F	TCGA-EO-A3B0	UCEC	TCGA	SHESGE	DEG_Kelch_Keap1_1	0.7982
p.S247F	DO219773	UCEC	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.7982
p.V243I	DO229010	COCA	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.2222
p.V243I	DO229227	THCA	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.2222
p.T245K	DO229037	LICA	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.2778
p.T259I	DO222731	MELA	ICGC	SHESGE	DEG_Kelch_Keap1_1	0.1389
p.T245P	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	SHESGE	DEG_Kelch_Keap1_1	0.2778
p.T245P	ACH-000888	Lung Cancer	CCLE	SHESGE	DEG_Kelch_Keap1_1	0.2778
p.T245P	NCI-H1793	lung	COSMIC	SHESGE	DEG_Kelch_Keap1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULC0	Endomucin	DEG_Kelch_Keap1_1	247:252	SHESGE	KEAP1	0.6007	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons