DegronMD - P05187(ALPP)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G162V	TCGA-05-4396	LUAD	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1944
p.G162V	DO23838	LUAD	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1944
p.P235T	TCGA-17-Z031	LUAD	TCGA	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.7031
p.V173M	TCGA-2A-A8VT	PRAD	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.V173M	DO219240	PRAD	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.T169I	TCGA-55-8299	LUAD	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7078
p.T169I	DO25927	LUAD	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7078
p.D236N	TCGA-92-8065	LUSC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.5821
p.D236N	DO27074	LUSC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.5821
p.V165A	TCGA-94-8490	LUSC	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.V165A	DO52021	LUSC	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.2778
p.D236Y	TCGA-A5-A0G1	UCEC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.6214
p.D236Y	DO42472	UCEC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.6214
p.A179T	TCGA-A6-A565	COAD	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1111
p.A179T	DO44090	COAD	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1111
p.A179T	DO50970	LICA	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1111
p.G180D	TCGA-D5-6922	COAD	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0833
p.G180D	DO8714	COAD	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0833
p.P178L	TCGA-EB-A5FP	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.P178L	DO47362	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.S177L	TCGA-EK-A2RA	CESC	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation blocking phosphorylation signal	0.6111
p.S177L	TCGA-YC-A89H	BLCA	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation blocking phosphorylation signal	0.6111
p.S177L	DO51948	BLCA	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation blocking phosphorylation signal	0.6111
p.S177L	DO51601	CESC	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation blocking phosphorylation signal	0.6111
p.R231C	TCGA-EY-A1GI	UCEC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.3056
p.R231C	DO41211	UCEC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.3056
p.R231C	SIDM00014	Colorectal Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.3056
p.R231C	LIM1215	large intestine	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.3056
p.G166R	TCGA-FW-A3R5	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.3056
p.G166R	DO37406	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.3056
p.G247E	TCGA-IB-7651	PAAD	TCGA	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.0833
p.G247E	DO46657	PAAD	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.0833
p.P240T	TCGA-NC-A5HE	LUSC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.2778
p.P240T	DO45453	LUSC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.2778
p.P240Q	TCGA-NC-A5HE	LUSC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.2778
p.P240Q	DO45453	LUSC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.2778
p.G224V	DO225046	BRCA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.1111
p.R226Q	DO225046	BRCA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.1667
p.R226Q	SIDM00493	Other Solid Cancers	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.1667
p.R226Q	SIDM00554	Ovarian Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.1667
p.P178S	DO225286	BRCA	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.P178S	DO227593	BRCA	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1389
p.R231P	DO229005	COCA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.3056
p.R231P	DO228947	LICA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.3056
p.R231P	DO229024	LICA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.3056
p.D242A	DO233641	GACA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.2222
p.K159N	DO229041	LICA	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation substituting flanking lysine	0.2222
p.A179G	DO231801	LINC	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1111
p.T181A	DO52365	LUSC	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	DO222708	MELA	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	SIDM01146	Gastric Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	SIDM00242	Osteosarcoma	GDSC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	SIDM01451	Pancreatic Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	SIDM01756	Chronic Myelogenous Leukemia	GDSC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	ACH-000076	Leukemia	CCLE	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	ACH-000932	Gastric Cancer	CCLE	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	ACH-000933	Pancreatic Cancer	CCLE	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	ACH-001664	Gastric Cancer	CCLE	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	ACH-002067	Bone Cancer	CCLE	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	NCI-SNU-1	stomach	COSMIC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.T181A	NOS-1	bone	COSMIC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0556
p.G180R	DO229259	THCA	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.0833
p.S244G	SIDM01265	Plasma Cell Myeloma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.6111
p.S244G	SIDM00808	Burkitt's Lymphoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.6111
p.S244G	SIDM00628	Breast Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.6111
p.S244G	SIDM01254	Burkitt's Lymphoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.6111
p.F230C	SIDM00193	Colorectal Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.2778
p.F230C	ACH-000991	Colon/Colorectal Cancer	CCLE	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.2778
p.F230C	SNU-81	large intestine	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.2778
p.Y239H	SIDM00596	Endometrial Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.75
p.Y239H	ACH-001517	Endometrial/Uterine Cancer	CCLE	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.75
p.Y239H	HEC-1	endometrium	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.75
p.E238Q	SIDM00150	Colorectal Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.6744
p.E238Q	ACH-000969	Colon/Colorectal Cancer	CCLE	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.6744
p.E238Q	KM12	large intestine	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.6744
p.G162R	SIDM01228	Melanoma	GDSC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation rewiring degron network	0.1944
p.G246S	Sarc9371	bone	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALPP

UniProt ID: P05187

Entrez ID: 250

Protein name: Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALPP in