DegronMD - P05187(ALPP)

FUNCTION: Alkaline phosphatase that can hydrolyze various phosphate compounds. {ECO:0000269|PubMed:1939159, ECO:0000269|PubMed:25775211}.

GO - Biological processes (BP): dephosphorylation [GO:0016311]

GO - Molecular function (MF): alkaline phosphatase activity [GO:0004035]; magnesium ion binding [GO:0000287]; zinc ion binding [GO:0008270]

GO - Cellular component (CC): anchored component of membrane [GO:0031225]; cell surface [GO:0009986]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y239H	SIDM00596	Endometrial Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.75
p.Y239H	ACH-001517	Endometrial/Uterine Cancer	CCLE	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.75
p.Y239H	HEC-1	endometrium	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.75
p.T169I	TCGA-55-8299	LUAD	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7078
p.T169I	DO25927	LUAD	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation altering degron motif	0.7078
p.P235T	TCGA-17-Z031	LUAD	TCGA	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.7031
p.E238Q	SIDM00150	Colorectal Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.6744
p.E238Q	ACH-000969	Colon/Colorectal Cancer	CCLE	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.6744
p.E238Q	KM12	large intestine	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.6744
p.D236Y	TCGA-A5-A0G1	UCEC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.6214
p.D236Y	DO42472	UCEC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.6214
p.S177L	TCGA-EK-A2RA	CESC	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation blocking phosphorylation signal	0.6111
p.S177L	TCGA-YC-A89H	BLCA	TCGA	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation blocking phosphorylation signal	0.6111
p.S177L	DO51948	BLCA	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation blocking phosphorylation signal	0.6111
p.S177L	DO51601	CESC	ICGC	VVTTT	DEG_SPOP_SBC_1	167:171	Mutation blocking phosphorylation signal	0.6111
p.S244G	SIDM01265	Plasma Cell Myeloma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.6111
p.S244G	SIDM00808	Burkitt's Lymphoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.6111
p.S244G	SIDM00628	Breast Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.6111
p.S244G	SIDM01254	Burkitt's Lymphoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation blocking phosphorylation signal	0.6111
p.D236N	TCGA-92-8065	LUSC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	232:238	Mutation altering degron motif	0.5821

Showing 1 to 20 of 78 entries

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No resistance data available for this Degron.

Kaplan plot for ALPP in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALPP

UniProt ID: P05187

Entrez ID: 250

Protein name: Alkaline phosphatase, placental type (EC 3.1.3.1) (Alkaline phosphatase Regan isozyme) (Placental alkaline phosphatase 1) (PLAP-1)

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for ALPP in