DegronMD

Uniprot ID: P05187

Source protein: Alkaline phosphatase, placental type

Source gene: ALPP

Class: DEG_SCF_FBW7_2

Location: 232:238

E3 ligase: FBXW7

DEGRON score: 0.7378

ASA_SCORE: 70.3571

COIL: 0.892

CONS_SCORE: 0.476

DSS_SCORE: 0.4949

HELIX: 0.0387

FCONS_SCORE: 0.8137

RIG_SCORE: 0.6872

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P235T	TCGA-17-Z031	LUAD	TCGA	MGTPDPE	DEG_SCF_FBW7_2	0.7031
p.D236N	TCGA-92-8065	LUSC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	0.5821
p.D236N	DO27074	LUSC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.5821
p.D236Y	TCGA-A5-A0G1	UCEC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	0.6214
p.D236Y	DO42472	UCEC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.6214
p.R231C	TCGA-EY-A1GI	UCEC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	0.3056
p.R231C	DO41211	UCEC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.3056
p.R231C	SIDM00014	Colorectal Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	0.3056
p.R231C	LIM1215	large_intestine	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	0.3056
p.G247E	TCGA-IB-7651	PAAD	TCGA	MGTPDPE	DEG_SCF_FBW7_2	0.0833
p.G247E	DO46657	PAAD	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.0833
p.P240T	TCGA-NC-A5HE	LUSC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	0.2778
p.P240T	DO45453	LUSC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.2778
p.P240Q	TCGA-NC-A5HE	LUSC	TCGA	MGTPDPE	DEG_SCF_FBW7_2	0.2778
p.P240Q	DO45453	LUSC	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.2778
p.G224V	DO225046	BRCA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.1111
p.R226Q	DO225046	BRCA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.1667
p.R226Q	SIDM00493	Other Solid Cancers	GDSC	MGTPDPE	DEG_SCF_FBW7_2	0.1667
p.R226Q	SIDM00554	Ovarian Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	0.1667
p.R231P	DO229005	COCA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.3056
p.R231P	DO228947	LICA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.3056
p.R231P	DO229024	LICA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.3056
p.D242A	DO233641	GACA	ICGC	MGTPDPE	DEG_SCF_FBW7_2	0.2222
p.S244G	SIDM01265	Plasma Cell Myeloma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	0.6111
p.S244G	SIDM00808	Burkitt's Lymphoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	0.6111
p.S244G	SIDM00628	Breast Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	0.6111
p.S244G	SIDM01254	Burkitt's Lymphoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	0.6111
p.F230C	SIDM00193	Colorectal Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	0.2778
p.F230C	ACH-000991	Colon/Colorectal Cancer	CCLE	MGTPDPE	DEG_SCF_FBW7_2	0.2778
p.F230C	SNU-81	large_intestine	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	0.2778
p.Y239H	SIDM00596	Endometrial Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	0.75
p.Y239H	ACH-001517	Endometrial/Uterine Cancer	CCLE	MGTPDPE	DEG_SCF_FBW7_2	0.75
p.Y239H	HEC-1	endometrium	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	0.75
p.E238Q	SIDM00150	Colorectal Carcinoma	GDSC	MGTPDPE	DEG_SCF_FBW7_2	0.6744
p.E238Q	ACH-000969	Colon/Colorectal Cancer	CCLE	MGTPDPE	DEG_SCF_FBW7_2	0.6744
p.E238Q	KM12	large_intestine	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	0.6744
p.G246S	Sarc9371	bone	COSMIC	MGTPDPE	DEG_SCF_FBW7_2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MGTPDPE

Degron related mutations and impact score

Drug responses associated with ALPP mutations

All proteins holding degron of MGTPDPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P05187	Alkaline phosphatase, placental type	DEG_SCF_FBW7_2	232:238	MGTPDPE	FBXW7	0.7378	More...