DegronMD

Uniprot ID: P05187

Source protein: Alkaline phosphatase, placental type

Source gene: ALPP

Class: DEG_SPOP_SBC_1

Location: 167:171

E3 ligase: SPOP

DEGRON score: 0.7745

ASA_SCORE: 31.94

COIL: 0.2586

CONS_SCORE: 0.7725

DSS_SCORE: 0.4779

HELIX: 0.0106

FCONS_SCORE: 1.0568

RIG_SCORE: 0.8023

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G162V	TCGA-05-4396	LUAD	TCGA	VVTTT	DEG_SPOP_SBC_1	0.1944
p.G162V	DO23838	LUAD	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1944
p.V173M	TCGA-2A-A8VT	PRAD	TCGA	VVTTT	DEG_SPOP_SBC_1	0.2778
p.V173M	DO219240	PRAD	ICGC	VVTTT	DEG_SPOP_SBC_1	0.2778
p.T169I	TCGA-55-8299	LUAD	TCGA	VVTTT	DEG_SPOP_SBC_1	0.7078
p.T169I	DO25927	LUAD	ICGC	VVTTT	DEG_SPOP_SBC_1	0.7078
p.V165A	TCGA-94-8490	LUSC	TCGA	VVTTT	DEG_SPOP_SBC_1	0.2778
p.V165A	DO52021	LUSC	ICGC	VVTTT	DEG_SPOP_SBC_1	0.2778
p.A179T	TCGA-A6-A565	COAD	TCGA	VVTTT	DEG_SPOP_SBC_1	0.1111
p.A179T	DO44090	COAD	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1111
p.A179T	DO50970	LICA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1111
p.G180D	TCGA-D5-6922	COAD	TCGA	VVTTT	DEG_SPOP_SBC_1	0.0833
p.G180D	DO8714	COAD	ICGC	VVTTT	DEG_SPOP_SBC_1	0.0833
p.P178L	TCGA-EB-A5FP	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	0.1389
p.P178L	DO47362	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1389
p.S177L	TCGA-EK-A2RA	CESC	TCGA	VVTTT	DEG_SPOP_SBC_1	0.6111
p.S177L	TCGA-YC-A89H	BLCA	TCGA	VVTTT	DEG_SPOP_SBC_1	0.6111
p.S177L	DO51948	BLCA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.6111
p.S177L	DO51601	CESC	ICGC	VVTTT	DEG_SPOP_SBC_1	0.6111
p.G166R	TCGA-FW-A3R5	SKCM	TCGA	VVTTT	DEG_SPOP_SBC_1	0.3056
p.G166R	DO37406	SKCM	ICGC	VVTTT	DEG_SPOP_SBC_1	0.3056
p.P178S	DO225286	BRCA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1389
p.P178S	DO227593	BRCA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1389
p.K159N	DO229041	LICA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.2222
p.A179G	DO231801	LINC	ICGC	VVTTT	DEG_SPOP_SBC_1	0.1111
p.T181A	DO52365	LUSC	ICGC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	DO222708	MELA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	SIDM01146	Gastric Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	SIDM00242	Osteosarcoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	SIDM01451	Pancreatic Carcinoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	SIDM01756	Chronic Myelogenous Leukemia	GDSC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	ACH-000076	Leukemia	CCLE	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	ACH-000932	Gastric Cancer	CCLE	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	ACH-000933	Pancreatic Cancer	CCLE	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	ACH-001664	Gastric Cancer	CCLE	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	ACH-002067	Bone Cancer	CCLE	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	NCI-SNU-1	stomach	COSMIC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.T181A	NOS-1	bone	COSMIC	VVTTT	DEG_SPOP_SBC_1	0.0556
p.G180R	DO229259	THCA	ICGC	VVTTT	DEG_SPOP_SBC_1	0.0833
p.G162R	SIDM01228	Melanoma	GDSC	VVTTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1642:1646	VVTTT	SPOP	0.908	More...
P05187	Alkaline phosphatase, placental type	DEG_SPOP_SBC_1	167:171	VVTTT	SPOP	0.7745	More...
P09923	Intestinal-type alkaline phosphatase	DEG_SPOP_SBC_1	164:168	VVTTT	SPOP	0.7745	More...
Q9ULC0	Endomucin	DEG_SPOP_SBC_1	32:36	VVTTT	SPOP	0.977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTTT

Degron related mutations and impact score

Drug responses associated with ALPP mutations

All proteins holding degron of VVTTT