DegronMD

Uniprot ID: O75179

Source protein: Ankyrin repeat domain-containing protein 17

Source gene: ANKRD17

Class: DEG_SCF_FBW7_1

Location: 2332:2337

E3 ligase: FBXW7

DEGRON score: 0.9362

ASA_SCORE: 65.8333

COIL: 0.8885

CONS_SCORE: 0.4114

DSS_SCORE: 0.4797

HELIX: 0.063

FCONS_SCORE: 1.0621

RIG_SCORE: 0.6489

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2327L	TCGA-B5-A11E	UCEC	TCGA	VTPSST	DEG_SCF_FBW7_1	0.1944
p.S2347L	TCGA-EB-A5SG	SKCM	TCGA	VTPSST	DEG_SCF_FBW7_1	0.0556
p.S2347L	SIDM00158	Glioblastoma	GDSC	VTPSST	DEG_SCF_FBW7_1	0.0556
p.S2347L	ACH-000623	Brain Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	0.0556
p.S2335I	DO223732	CESC	ICGC	VTPSST	DEG_SCF_FBW7_1	0.623
p.G2326V	DO37412	SKCM	ICGC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.G2326V	NB17	autonomic_ganglia	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.G2326V	NBsusSR	autonomic_ganglia	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.T2327M	DO42568	UCEC	ICGC	VTPSST	DEG_SCF_FBW7_1	0.1944
p.T2327M	DO41235	UCEC	ICGC	VTPSST	DEG_SCF_FBW7_1	0.1944
p.T2327M	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.1944
p.N2324D	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	0.1111
p.N2324D	ACH-000444	Lung Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	0.1111
p.N2324D	LU-99A	lung	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.1111
p.M2325T	SIDM00989	Bladder Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	0.1389
p.M2325T	BFTC-905	urinary_tract	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.1389
p.H2338Q	ACH-000586	Lung Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	0.3056
p.H2338Q	NCI-H1876	lung	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.3056
p.V2332I	TE-10	oesophagus	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.5965
p.N2328K	G-402	soft_tissue	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SCF_FBW7_1	2332:2337	VTPSST	FBXW7	0.9362	More...
Q16186	Proteasomal ubiquitin receptor ADRM1	DEG_SCF_FBW7_1	216:221	VTPSST	FBXW7	0.9893	More...
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	DEG_SCF_FBW7_1	562:567	VTPSST	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons