DegronMD - Q16186(ADRM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P218S	TCGA-06-0214	GBM	TCGA	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation altering degron motif	0.6752
p.P218S	TCGA-06-0214	GBM	TCGA	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6752
p.P218S	DO10960	GBM	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation altering degron motif	0.6752
p.P218S	DO10960	GBM	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6752
p.R210Q	TCGA-A5-A1OF	UCEC	TCGA	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1667
p.R210Q	TCGA-A5-A1OF	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.R210Q	TCGA-A5-A1OF	UCEC	TCGA	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.R210Q	DO42568	UCEC	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1667
p.R210Q	DO42568	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.R210Q	DO42568	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.P229T	TCGA-CR-7404	HNSC	TCGA	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1111
p.P229T	TCGA-CR-7404	HNSC	TCGA	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.P229T	DO14420	HNSC	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1111
p.P229T	DO14420	HNSC	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.R210L	TCGA-D3-A2JC	SKCM	TCGA	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1667
p.R210L	TCGA-D3-A2JC	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.R210L	TCGA-D3-A2JC	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.R210L	DO47578	SKCM	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1667
p.R210L	DO47578	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.R210L	DO47578	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.G196V	TCGA-DK-A2I1	BLCA	TCGA	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.G196V	DO444	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.P218T	TCGA-EB-A24C	SKCM	TCGA	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation altering degron motif	0.7031
p.P218T	TCGA-EB-A24C	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7031
p.P218T	DO37438	SKCM	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation altering degron motif	0.7031
p.P218T	DO37438	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7031
p.A215V	TCGA-EO-A22U	UCEC	TCGA	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.3056
p.A215V	TCGA-EO-A22U	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.0556
p.A215V	TCGA-EO-A22U	UCEC	TCGA	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.25
p.A215V	DO43755	UCEC	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.3056
p.A215V	DO43755	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.0556
p.A215V	DO43755	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.25
p.T225P	DO48389	BLCA	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.2222
p.T225P	DO48389	BLCA	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.25
p.S219L	DO3110	BRCA	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation altering degron motif	0.7667
p.S219L	DO3110	BRCA	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7667
p.R210W	DO233867	GACA	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1667
p.R210W	DO233867	GACA	ICGC	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.1944
p.R210W	DO233867	GACA	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.V216F	DO229037	LICA	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation altering degron motif	0.7068
p.S206F	DO228419	MALY	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.0556
p.S206F	DO228419	MALY	ICGC	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation rewiring degron network	0.3056
p.T225I	DO228584	MALY	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.2222
p.T225I	DO228584	MALY	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.25
p.T221A	DO46538	OV	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation altering degron motif	0.825
p.T221A	DO46538	OV	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.825
p.R226C	DO51133	PRAD	ICGC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation rewiring degron network	0.1944
p.R226C	DO51133	PRAD	ICGC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2222
p.P201Q	SIDM00373	Endometrial Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation altering degron motif	0.7035
p.P201Q	ACH-000974	Endometrial/Uterine Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	201:205	Mutation altering degron motif	0.7035
p.T217A	ACH-000999	Colon/Colorectal Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation altering degron motif	0.825
p.Q224E	NB1	autonomic ganglia	COSMIC	VTPSST	DEG_SCF_FBW7_1	216:221	Mutation blocking phosphorylation signal	0.6944
p.Q224E	NB1	autonomic ganglia	COSMIC	PSSTT	DEG_SPOP_SBC_1	218:222	Mutation blocking phosphorylation signal	0.7222

Kaplan plot for ADRM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADRM1

UniProt ID: Q16186

Entrez ID: 11047

Protein name: Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADRM1 in