DegronMD

Uniprot ID: Q16186

Source protein: Proteasomal ubiquitin receptor ADRM1

Source gene: ADRM1

Class: DEG_SCF_FBW7_1

Location: 216:221

E3 ligase: FBXW7

DEGRON score: 0.9893

ASA_SCORE: 83.9667

COIL: 0.9292

CONS_SCORE: 0.1499

DSS_SCORE: 0.6546

HELIX: 0.0388

FCONS_SCORE: 0.6003

RIG_SCORE: 0.5484

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P218S	TCGA-06-0214	GBM	TCGA	VTPSST	DEG_SCF_FBW7_1	0.6752
p.P218S	DO10960	GBM	ICGC	VTPSST	DEG_SCF_FBW7_1	0.6752
p.R210Q	TCGA-A5-A1OF	UCEC	TCGA	VTPSST	DEG_SCF_FBW7_1	0.1667
p.R210Q	DO42568	UCEC	ICGC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.P229T	TCGA-CR-7404	HNSC	TCGA	VTPSST	DEG_SCF_FBW7_1	0.1111
p.P229T	DO14420	HNSC	ICGC	VTPSST	DEG_SCF_FBW7_1	0.1111
p.R210L	TCGA-D3-A2JC	SKCM	TCGA	VTPSST	DEG_SCF_FBW7_1	0.1667
p.R210L	DO47578	SKCM	ICGC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.P218T	TCGA-EB-A24C	SKCM	TCGA	VTPSST	DEG_SCF_FBW7_1	0.7031
p.P218T	DO37438	SKCM	ICGC	VTPSST	DEG_SCF_FBW7_1	0.7031
p.A215V	TCGA-EO-A22U	UCEC	TCGA	VTPSST	DEG_SCF_FBW7_1	0.3056
p.A215V	DO43755	UCEC	ICGC	VTPSST	DEG_SCF_FBW7_1	0.3056
p.T225P	DO48389	BLCA	ICGC	VTPSST	DEG_SCF_FBW7_1	0.2222
p.S219L	DO3110	BRCA	ICGC	VTPSST	DEG_SCF_FBW7_1	0.7667
p.R210W	DO233867	GACA	ICGC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.V216F	DO229037	LICA	ICGC	VTPSST	DEG_SCF_FBW7_1	0.7068
p.S206F	DO228419	MALY	ICGC	VTPSST	DEG_SCF_FBW7_1	0.0556
p.T225I	DO228584	MALY	ICGC	VTPSST	DEG_SCF_FBW7_1	0.2222
p.T221A	DO46538	OV	ICGC	VTPSST	DEG_SCF_FBW7_1	0.825
p.R226C	DO51133	PRAD	ICGC	VTPSST	DEG_SCF_FBW7_1	0.1944
p.T217A	ACH-000999	Colon/Colorectal Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	0.825
p.Q224E	NB1	autonomic_ganglia	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SCF_FBW7_1	2332:2337	VTPSST	FBXW7	0.9362	More...
Q16186	Proteasomal ubiquitin receptor ADRM1	DEG_SCF_FBW7_1	216:221	VTPSST	FBXW7	0.9893	More...
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	DEG_SCF_FBW7_1	562:567	VTPSST	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons