DegronMD

Uniprot ID: Q8IZT6

Source protein: Abnormal spindle-like microcephaly-associated protein

Source gene: ASPM

Class: DEG_SCF_FBW7_1

Location: 562:567

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 78.2333

COIL: 0.8957

CONS_SCORE: 0.3124

DSS_SCORE: 0.5049

HELIX: 0.049

FCONS_SCORE: 1.0805

RIG_SCORE: 0.674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K556N	TCGA-AG-A002	READ	TCGA	VTPSST	DEG_SCF_FBW7_1	0.2778
p.V571L	TCGA-BB-A5HY	HNSC	TCGA	VTPSST	DEG_SCF_FBW7_1	0.2222
p.V571L	DO218979	HNSC	ICGC	VTPSST	DEG_SCF_FBW7_1	0.2222
p.S557C	TCGA-BR-8080	STAD	TCGA	VTPSST	DEG_SCF_FBW7_1	0.1944
p.S557C	DO38651	STAD	ICGC	VTPSST	DEG_SCF_FBW7_1	0.1944
p.K556E	TCGA-CV-5435	HNSC	TCGA	VTPSST	DEG_SCF_FBW7_1	0.2778
p.K556E	DO14299	HNSC	ICGC	VTPSST	DEG_SCF_FBW7_1	0.2778
p.S565T	TCGA-CV-5973	HNSC	TCGA	VTPSST	DEG_SCF_FBW7_1	0.7116
p.S565T	DO15014	HNSC	ICGC	VTPSST	DEG_SCF_FBW7_1	0.7116
p.A572D	DO229018	LICA	ICGC	VTPSST	DEG_SCF_FBW7_1	0.1944
p.T563K	DO229038	LICA	ICGC	VTPSST	DEG_SCF_FBW7_1	0.8417
p.S566L	SIDM02021	Esophageal Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	0.6556
p.S566L	SIDM00215	Colorectal Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	0.6556
p.S566L	ACH-000460	Ovarian Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	0.6556
p.S566L	ACH-000708	Colon/Colorectal Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	0.6556
p.S566L	SNU-283	large_intestine	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.6556
p.R573W	SIDM01006	Plasma Cell Myeloma	GDSC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.R573W	SIDM00741	Small Cell Lung Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.R573W	SIDM00522	Small Cell Lung Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.R573W	SIDM00888	Other Solid Cancers	GDSC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.R573W	SIDM00833	Colorectal Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	0.1667
p.S570L	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	0.6944
p.S570L	ACH-000744	Lung Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	0.6944
p.S570L	NCI-H1623	lung	COSMIC	VTPSST	DEG_SCF_FBW7_1	0.6944
p.R573Q	ACH-001523	Skin Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SCF_FBW7_1	2332:2337	VTPSST	FBXW7	0.9362	More...
Q16186	Proteasomal ubiquitin receptor ADRM1	DEG_SCF_FBW7_1	216:221	VTPSST	FBXW7	0.9893	More...
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	DEG_SCF_FBW7_1	562:567	VTPSST	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTPSST

Degron related mutations and impact score

Drug responses associated with ASPM mutations

All proteins holding degron of VTPSST