DegronMD - Q8IZT6(ASPM)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A2393S	TCGA-55-7907	LUAD	TCGA	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation altering degron motif	0.6477
p.A2393S	DO25396	LUAD	ICGC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation altering degron motif	0.6477
p.R3444I	TCGA-55-7994	LUAD	TCGA	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation rewiring degron network	0.1944
p.R3444I	DO45311	LUAD	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation rewiring degron network	0.1944
p.E292K	TCGA-5L-AAT1	BRCA	TCGA	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.2222
p.E292K	DO219594	BRCA	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.2222
p.K2405N	TCGA-86-8673	LUAD	TCGA	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation blocking ubiquitination signal	0.6667
p.K2405N	DO26260	LUAD	ICGC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation blocking ubiquitination signal	0.6667
p.R2184Q	TCGA-A2-A0SY	BRCA	TCGA	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation rewiring degron network	0.3056
p.R2184Q	TCGA-A5-A0G2	UCEC	TCGA	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation rewiring degron network	0.3056
p.R2184Q	DO2961	BRCA	ICGC	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation rewiring degron network	0.3056
p.R2184Q	DO41235	UCEC	ICGC	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation rewiring degron network	0.3056
p.K2405Q	TCGA-A5-A0G2	UCEC	TCGA	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation blocking ubiquitination signal	0.6667
p.K2405Q	DO41235	UCEC	ICGC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation blocking ubiquitination signal	0.6667
p.K3423N	TCGA-A5-A2K5	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking ubiquitination signal	0.5278
p.K3423N	TCGA-EO-A22U	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking ubiquitination signal	0.5278
p.K3423N	DO43755	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking ubiquitination signal	0.5278
p.K3423N	DO41379	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking ubiquitination signal	0.5278
p.L306F	TCGA-AA-3984	COAD	TCGA	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.25
p.L306F	DO9002	COAD	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.25
p.K556N	TCGA-AG-A002	READ	TCGA	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation substituting flanking lysine	0.2778
p.K556N	TCGA-AG-A002	READ	TCGA	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation substituting flanking lysine	0.2222
p.T2165I	TCGA-AJ-A3BG	UCEC	TCGA	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation rewiring degron network	0.1111
p.T2165I	DO42633	UCEC	ICGC	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation rewiring degron network	0.1111
p.S3425F	TCGA-AP-A059	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking phosphorylation signal	0.5833
p.S3425F	DO41361	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking phosphorylation signal	0.5833
p.R2402T	TCGA-AZ-6608	COAD	TCGA	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation rewiring degron network	0.3056
p.R2402T	DO7954	COAD	ICGC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation rewiring degron network	0.3056
p.R2396M	TCGA-B5-A11E	UCEC	TCGA	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation altering degron motif	0.8632
p.R2396M	DO41644	UCEC	ICGC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation altering degron motif	0.8632
p.V571L	TCGA-BB-A5HY	HNSC	TCGA	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.2222
p.V571L	TCGA-BB-A5HY	HNSC	TCGA	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.V571L	DO218979	HNSC	ICGC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.2222
p.V571L	DO218979	HNSC	ICGC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.25
p.Y2163C	TCGA-BR-6452	STAD	TCGA	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation rewiring degron network	0.0556
p.Y2163C	DO38404	STAD	ICGC	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation rewiring degron network	0.0556
p.S557C	TCGA-BR-8080	STAD	TCGA	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.1944
p.S557C	TCGA-BR-8080	STAD	TCGA	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.S557C	DO38651	STAD	ICGC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.1944
p.S557C	DO38651	STAD	ICGC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1389
p.R2383T	TCGA-CV-5430	HNSC	TCGA	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation rewiring degron network	0.1111
p.R2383T	DO14270	HNSC	ICGC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation rewiring degron network	0.1111
p.K556E	TCGA-CV-5435	HNSC	TCGA	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation substituting flanking lysine	0.2778
p.K556E	TCGA-CV-5435	HNSC	TCGA	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation substituting flanking lysine	0.2222
p.K556E	DO14299	HNSC	ICGC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation substituting flanking lysine	0.2778
p.K556E	DO14299	HNSC	ICGC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation substituting flanking lysine	0.2222
p.S565T	TCGA-CV-5973	HNSC	TCGA	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation altering degron motif	0.7116
p.S565T	TCGA-CV-5973	HNSC	TCGA	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7116
p.S565T	DO15014	HNSC	ICGC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation altering degron motif	0.7116
p.S565T	DO15014	HNSC	ICGC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7116
p.L298P	TCGA-CV-5979	HNSC	TCGA	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.6471
p.L298P	DO14178	HNSC	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.6471
p.F3431C	TCGA-D1-A16X	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation rewiring degron network	0.3056
p.F3431C	DO41799	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation rewiring degron network	0.3056
p.S3425Y	TCGA-DF-A2KU	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking phosphorylation signal	0.5833
p.S3425Y	TCGA-E6-A1M0	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking phosphorylation signal	0.5833
p.S3425Y	TCGA-EO-A3AY	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking phosphorylation signal	0.5833
p.S3425Y	TCGA-EY-A1GI	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking phosphorylation signal	0.5833
p.S3425Y	DO43682	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking phosphorylation signal	0.5833
p.S3425Y	DO223286	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking phosphorylation signal	0.5833
p.S3425Y	DO43202	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking phosphorylation signal	0.5833
p.S3425Y	DO41211	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation blocking phosphorylation signal	0.5833
p.V2180E	TCGA-DM-A285	COAD	TCGA	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation altering degron motif	0.6582
p.V2180E	DO9490	COAD	ICGC	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation altering degron motif	0.6582
p.D578N	TCGA-EY-A1GD	UCEC	TCGA	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	DO42129	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM00194	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM00308	Chronic Myelogenous Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM00394	Cervical Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM00280	Gastric Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM01611	Endometrial Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM00500	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM00171	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM00016	Neuroblastoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM00162	Biliary Tract Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.D578N	SIDM01619	Endometrial Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.0556
p.S304L	TCGA-IR-A3LI	CESC	TCGA	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.3056
p.S304L	DO44400	CESC	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.3056
p.E3434K	DO228064	EOPC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation altering degron motif	0.591
p.S294I	DO234352	ESAD	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.2778
p.N307S	DO223046	ESCA	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.2222
p.S294N	DO233869	GACA	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.2778
p.R2396G	DO233867	GACA	ICGC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation altering degron motif	0.7568
p.A572D	DO229018	LICA	ICGC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.1944
p.A572D	DO229018	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.2222
p.T568K	DO229026	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7306
p.P3447T	DO229038	LICA	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation rewiring degron network	0.1111
p.T563K	DO229038	LICA	ICGC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation altering degron motif	0.8417
p.P3433Q	DO229045	LICA	ICGC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation altering degron motif	0.5924
p.Q310R	DO44802	LICA	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.1389
p.R2184W	DO231893	LINC	ICGC	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation rewiring degron network	0.3056
p.G2397S	DO50729	ORCA	ICGC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation altering degron motif	0.6993
p.S566L	SIDM02021	Esophageal Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation altering degron motif	0.6556
p.S566L	SIDM02021	Esophageal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7667
p.S566L	SIDM00215	Colorectal Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation altering degron motif	0.6556
p.S566L	SIDM00215	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7667
p.S566L	ACH-000460	Ovarian Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation altering degron motif	0.6556
p.S566L	ACH-000460	Ovarian Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7667
p.S566L	ACH-000708	Colon/Colorectal Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation altering degron motif	0.6556
p.S566L	ACH-000708	Colon/Colorectal Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7667
p.S566L	SNU-283	large intestine	COSMIC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation altering degron motif	0.6556
p.S566L	SNU-283	large intestine	COSMIC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation altering degron motif	0.7667
p.R2385I	SIDM00541	Colorectal Carcinoma	GDSC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation rewiring degron network	0.1667
p.R2385I	ACH-000926	Colon/Colorectal Cancer	CCLE	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation rewiring degron network	0.1667
p.R2385I	HT55	large intestine	COSMIC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation rewiring degron network	0.1667
p.I313V	SIDM00993	Plasma Cell Myeloma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM00425	Ovarian Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM00377	Other Sarcomas	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM00544	Neuroblastoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM00555	Glioblastoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM01196	Hepatocellular Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM00287	B-Lymphoblastic Leukemia	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM00580	Acute Myeloid Leukemia	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM01460	Glioma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM01494	Glioblastoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.I313V	SIDM01447	Glioblastoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0556
p.R573W	SIDM01006	Plasma Cell Myeloma	GDSC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.1667
p.R573W	SIDM01006	Plasma Cell Myeloma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1944
p.R573W	SIDM00741	Small Cell Lung Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.1667
p.R573W	SIDM00741	Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1944
p.R573W	SIDM00522	Small Cell Lung Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.1667
p.R573W	SIDM00522	Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1944
p.R573W	SIDM00888	Other Solid Cancers	GDSC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.1667
p.R573W	SIDM00888	Other Solid Cancers	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1944
p.R573W	SIDM00833	Colorectal Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.1667
p.R573W	SIDM00833	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1944
p.A2393T	SIDM00545	Melanoma	GDSC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation altering degron motif	0.6028
p.A2393T	ACH-000987	Skin Cancer	CCLE	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation altering degron motif	0.6028
p.A2393T	Mewo	skin	COSMIC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation altering degron motif	0.6028
p.C302Y	SIDM00572	Gastric Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.5976
p.C302Y	SIDM00242	Osteosarcoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.5976
p.C302Y	SIDM00045	Gastric Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.5976
p.C302Y	SIDM00531	Pancreatic Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.5976
p.C302Y	SIDM01318	Hepatocellular Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.5976
p.C302Y	SIDM00008	Ovarian Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.5976
p.C302Y	SIDM01435	Hepatocellular Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.5976
p.C302Y	SIDM00171	Colorectal Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.5976
p.C302Y	SIDM01442	Glioma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation altering degron motif	0.5976
p.I3432N	SIDM00266	Ewing's Sarcoma	GDSC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation altering degron motif	0.728
p.I3432N	ACH-002103	Bone Cancer	CCLE	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation altering degron motif	0.728
p.I3432N	ES1	bone	COSMIC	IPETPVRT	DEG_SCF_FBW7_1	3432:3439	Mutation altering degron motif	0.728
p.G288C	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.1111
p.G288C	ACH-000785	Lung Cancer	CCLE	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.1111
p.G288C	NCI-H2126	lung	COSMIC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.1111
p.S2410F	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation rewiring degron network	0.0833
p.S2410F	ACH-000886	Lung Cancer	CCLE	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation rewiring degron network	0.0833
p.S2410F	NCI-H2009	lung	COSMIC	LQAAFRGMKTR	SCF_FBXL2	2391:2401	Mutation rewiring degron network	0.0833
p.S570L	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation blocking phosphorylation signal	0.6944
p.S570L	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation blocking phosphorylation signal	0.7222
p.S570L	ACH-000744	Lung Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation blocking phosphorylation signal	0.6944
p.S570L	ACH-000744	Lung Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation blocking phosphorylation signal	0.7222
p.S570L	NCI-H1623	lung	COSMIC	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation blocking phosphorylation signal	0.6944
p.S570L	NCI-H1623	lung	COSMIC	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation blocking phosphorylation signal	0.7222
p.S311T	SIDM00850	Gastric Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.1111
p.S311T	AGS	stomach	COSMIC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.1111
p.R573Q	ACH-001523	Skin Cancer	CCLE	VTPSST	DEG_SCF_FBW7_1	562:567	Mutation rewiring degron network	0.1667
p.R573Q	ACH-001523	Skin Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	564:568	Mutation rewiring degron network	0.1944
p.A2169T	ACH-002061	Leukemia	CCLE	LQASFRGVRVR	SCF_FBXL2	2173:2183	Mutation rewiring degron network	0.2222
p.K293T	Hs683	central nervous system	COSMIC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.25
p.N312H	LCLC-97TM1	lung	COSMIC	LSLTPNCS	DEG_SCF_FBW7_1	296:303	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASPM

UniProt ID: Q8IZT6

Entrez ID: 259266

Protein name: Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASPM in