DegronMD

Uniprot ID: Q8IZT6

Source protein: Abnormal spindle-like microcephaly-associated protein

Source gene: ASPM

Class: DEG_SCF_FBW7_1

Location: 296:303

E3 ligase: FBXW7

DEGRON score: 0.9945

ASA_SCORE: 70.275

COIL: 0.8553

CONS_SCORE: 0.3357

DSS_SCORE: 0.4327

HELIX: 0.0429

FCONS_SCORE: 1.1683

RIG_SCORE: 0.7356

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E292K	TCGA-5L-AAT1	BRCA	TCGA	LSLTPNCS	DEG_SCF_FBW7_1	0.2222
p.E292K	DO219594	BRCA	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	0.2222
p.L306F	TCGA-AA-3984	COAD	TCGA	LSLTPNCS	DEG_SCF_FBW7_1	0.25
p.L306F	DO9002	COAD	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	0.25
p.L298P	TCGA-CV-5979	HNSC	TCGA	LSLTPNCS	DEG_SCF_FBW7_1	0.6471
p.L298P	DO14178	HNSC	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	0.6471
p.S304L	TCGA-IR-A3LI	CESC	TCGA	LSLTPNCS	DEG_SCF_FBW7_1	0.3056
p.S304L	DO44400	CESC	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	0.3056
p.S294I	DO234352	ESAD	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	0.2778
p.N307S	DO223046	ESCA	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	0.2222
p.S294N	DO233869	GACA	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	0.2778
p.Q310R	DO44802	LICA	ICGC	LSLTPNCS	DEG_SCF_FBW7_1	0.1389
p.I313V	SIDM00993	Plasma Cell Myeloma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM00425	Ovarian Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM00377	Other Sarcomas	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM00544	Neuroblastoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM00555	Glioblastoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM01196	Hepatocellular Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM00287	B-Lymphoblastic Leukemia	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM00580	Acute Myeloid Leukemia	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM01460	Glioma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM01494	Glioblastoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.I313V	SIDM01447	Glioblastoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.0556
p.C302Y	SIDM00572	Gastric Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.5976
p.C302Y	SIDM00242	Osteosarcoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.5976
p.C302Y	SIDM00045	Gastric Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.5976
p.C302Y	SIDM00531	Pancreatic Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.5976
p.C302Y	SIDM01318	Hepatocellular Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.5976
p.C302Y	SIDM00008	Ovarian Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.5976
p.C302Y	SIDM01435	Hepatocellular Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.5976
p.C302Y	SIDM00171	Colorectal Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.5976
p.C302Y	SIDM01442	Glioma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.5976
p.G288C	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.1111
p.G288C	ACH-000785	Lung Cancer	CCLE	LSLTPNCS	DEG_SCF_FBW7_1	0.1111
p.G288C	NCI-H2126	lung	COSMIC	LSLTPNCS	DEG_SCF_FBW7_1	0.1111
p.S311T	SIDM00850	Gastric Carcinoma	GDSC	LSLTPNCS	DEG_SCF_FBW7_1	0.1111
p.S311T	AGS	stomach	COSMIC	LSLTPNCS	DEG_SCF_FBW7_1	0.1111
p.K293T	Hs683	central_nervous_system	COSMIC	LSLTPNCS	DEG_SCF_FBW7_1	0.25
p.N312H	LCLC-97TM1	lung	COSMIC	LSLTPNCS	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSLTPNCS

Degron related mutations and impact score

Drug responses associated with ASPM mutations

All proteins holding degron of LSLTPNCS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	DEG_SCF_FBW7_1	296:303	LSLTPNCS	FBXW7	0.9945	More...