DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IPETPVRT
Uniprot ID:
Q8IZT6
Source protein:
Abnormal spindle-like microcephaly-associated protein
Source gene:
ASPM
Class:
DEG_SCF_FBW7_1
Location:
3432:3439
E3 ligase:
FBXW7
DEGRON score:
0.7486
ASA_SCORE:
101.45
COIL:
0.9298
CONS_SCORE:
0.3054
DSS_SCORE:
0.2463
HELIX:
0.0158
FCONS_SCORE:
0.884
RIG_SCORE:
0.7921
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R3444I
TCGA-55-7994
LUAD
TCGA
IPETPVRT
DEG_SCF_FBW7_1
0.1944
p.R3444I
DO45311
LUAD
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.1944
p.K3423N
TCGA-A5-A2K5
UCEC
TCGA
IPETPVRT
DEG_SCF_FBW7_1
0.5278
p.K3423N
TCGA-EO-A22U
UCEC
TCGA
IPETPVRT
DEG_SCF_FBW7_1
0.5278
p.K3423N
DO43755
UCEC
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.5278
p.K3423N
DO41379
UCEC
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.5278
p.S3425F
TCGA-AP-A059
UCEC
TCGA
IPETPVRT
DEG_SCF_FBW7_1
0.5833
p.S3425F
DO41361
UCEC
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.5833
p.F3431C
TCGA-D1-A16X
UCEC
TCGA
IPETPVRT
DEG_SCF_FBW7_1
0.3056
p.F3431C
DO41799
UCEC
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.3056
p.S3425Y
TCGA-DF-A2KU
UCEC
TCGA
IPETPVRT
DEG_SCF_FBW7_1
0.5833
p.S3425Y
TCGA-E6-A1M0
UCEC
TCGA
IPETPVRT
DEG_SCF_FBW7_1
0.5833
p.S3425Y
TCGA-EO-A3AY
UCEC
TCGA
IPETPVRT
DEG_SCF_FBW7_1
0.5833
p.S3425Y
TCGA-EY-A1GI
UCEC
TCGA
IPETPVRT
DEG_SCF_FBW7_1
0.5833
p.S3425Y
DO43682
UCEC
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.5833
p.S3425Y
DO223286
UCEC
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.5833
p.S3425Y
DO43202
UCEC
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.5833
p.S3425Y
DO41211
UCEC
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.5833
p.E3434K
DO228064
EOPC
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.591
p.P3447T
DO229038
LICA
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.1111
p.P3433Q
DO229045
LICA
ICGC
IPETPVRT
DEG_SCF_FBW7_1
0.5924
p.I3432N
SIDM00266
Ewing's Sarcoma
GDSC
IPETPVRT
DEG_SCF_FBW7_1
0.728
p.I3432N
ACH-002103
Bone Cancer
CCLE
IPETPVRT
DEG_SCF_FBW7_1
0.728
p.I3432N
ES1
bone
COSMIC
IPETPVRT
DEG_SCF_FBW7_1
0.728
Drug responses associated with ASPM mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IPETPVRT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IZT6
Abnormal spindle-like microcephaly-associated protein
DEG_SCF_FBW7_1
3432:3439
IPETPVRT
FBXW7
0.7486
More...