DegronMD

Uniprot ID: Q8IZT6

Source protein: Abnormal spindle-like microcephaly-associated protein

Source gene: ASPM

Class: DEG_SCF_FBW7_1

Location: 3432:3439

E3 ligase: FBXW7

DEGRON score: 0.7486

ASA_SCORE: 101.45

COIL: 0.9298

CONS_SCORE: 0.3054

DSS_SCORE: 0.2463

HELIX: 0.0158

FCONS_SCORE: 0.884

RIG_SCORE: 0.7921

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I3432N	SIDM00266	Ewing's Sarcoma	GDSC	IPETPVRT	DEG_SCF_FBW7_1	0.728
p.I3432N	ACH-002103	Bone Cancer	CCLE	IPETPVRT	DEG_SCF_FBW7_1	0.728
p.I3432N	ES1	bone	COSMIC	IPETPVRT	DEG_SCF_FBW7_1	0.728
p.P3433Q	DO229045	LICA	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.5924
p.E3434K	DO228064	EOPC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.591
p.S3425F	TCGA-AP-A059	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	0.5833
p.S3425F	DO41361	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.5833
p.S3425Y	TCGA-DF-A2KU	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	0.5833
p.S3425Y	TCGA-E6-A1M0	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	0.5833
p.S3425Y	TCGA-EO-A3AY	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	0.5833
p.S3425Y	TCGA-EY-A1GI	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	0.5833
p.S3425Y	DO43682	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.5833
p.S3425Y	DO223286	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.5833
p.S3425Y	DO43202	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.5833
p.S3425Y	DO41211	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.5833
p.K3423N	TCGA-A5-A2K5	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	0.5278
p.K3423N	TCGA-EO-A22U	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	0.5278
p.K3423N	DO43755	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.5278
p.K3423N	DO41379	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.5278
p.F3431C	TCGA-D1-A16X	UCEC	TCGA	IPETPVRT	DEG_SCF_FBW7_1	0.3056
p.F3431C	DO41799	UCEC	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.3056
p.R3444I	TCGA-55-7994	LUAD	TCGA	IPETPVRT	DEG_SCF_FBW7_1	0.1944
p.R3444I	DO45311	LUAD	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.1944
p.P3447T	DO229038	LICA	ICGC	IPETPVRT	DEG_SCF_FBW7_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	DEG_SCF_FBW7_1	3432:3439	IPETPVRT	FBXW7	0.7486	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons