DegronMD

Uniprot ID: Q8IZT6

Source protein: Abnormal spindle-like microcephaly-associated protein

Source gene: ASPM

Class: SCF_FBXL2

Location: 2173:2183

E3 ligase: FBXL2

DEGRON score: 0.5387

ASA_SCORE: 55

COIL: 0.016

CONS_SCORE: 0.5172

DSS_SCORE: 0.1277

HELIX: 0.9835

FCONS_SCORE: 1.3663

RIG_SCORE: 0.8664

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2184Q	TCGA-A2-A0SY	BRCA	TCGA	LQASFRGVRVR	SCF_FBXL2	0.3056
p.R2184Q	TCGA-A5-A0G2	UCEC	TCGA	LQASFRGVRVR	SCF_FBXL2	0.3056
p.R2184Q	DO2961	BRCA	ICGC	LQASFRGVRVR	SCF_FBXL2	0.3056
p.R2184Q	DO41235	UCEC	ICGC	LQASFRGVRVR	SCF_FBXL2	0.3056
p.T2165I	TCGA-AJ-A3BG	UCEC	TCGA	LQASFRGVRVR	SCF_FBXL2	0.1111
p.T2165I	DO42633	UCEC	ICGC	LQASFRGVRVR	SCF_FBXL2	0.1111
p.Y2163C	TCGA-BR-6452	STAD	TCGA	LQASFRGVRVR	SCF_FBXL2	0.0556
p.Y2163C	DO38404	STAD	ICGC	LQASFRGVRVR	SCF_FBXL2	0.0556
p.V2180E	TCGA-DM-A285	COAD	TCGA	LQASFRGVRVR	SCF_FBXL2	0.6582
p.V2180E	DO9490	COAD	ICGC	LQASFRGVRVR	SCF_FBXL2	0.6582
p.R2184W	DO231893	LINC	ICGC	LQASFRGVRVR	SCF_FBXL2	0.3056
p.A2169T	ACH-002061	Leukemia	CCLE	LQASFRGVRVR	SCF_FBXL2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	SCF_FBXL2	2173:2183	LQASFRGVRVR	FBXL2	0.5387	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons