DegronMD

Uniprot ID: Q8IZT6

Source protein: Abnormal spindle-like microcephaly-associated protein

Source gene: ASPM

Class: SCF_FBXL2

Location: 2391:2401

E3 ligase: FBXL2

DEGRON score: 0.5744

ASA_SCORE: 42.1455

COIL: 0.0022

CONS_SCORE: 0.4889

DSS_SCORE: 0.363

HELIX: 0.9976

FCONS_SCORE: 1.3263

RIG_SCORE: 0.7676

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2393S	TCGA-55-7907	LUAD	TCGA	LQAAFRGMKTR	SCF_FBXL2	0.6477
p.A2393S	DO25396	LUAD	ICGC	LQAAFRGMKTR	SCF_FBXL2	0.6477
p.K2405N	TCGA-86-8673	LUAD	TCGA	LQAAFRGMKTR	SCF_FBXL2	0.6667
p.K2405N	DO26260	LUAD	ICGC	LQAAFRGMKTR	SCF_FBXL2	0.6667
p.K2405Q	TCGA-A5-A0G2	UCEC	TCGA	LQAAFRGMKTR	SCF_FBXL2	0.6667
p.K2405Q	DO41235	UCEC	ICGC	LQAAFRGMKTR	SCF_FBXL2	0.6667
p.R2402T	TCGA-AZ-6608	COAD	TCGA	LQAAFRGMKTR	SCF_FBXL2	0.3056
p.R2402T	DO7954	COAD	ICGC	LQAAFRGMKTR	SCF_FBXL2	0.3056
p.R2396M	TCGA-B5-A11E	UCEC	TCGA	LQAAFRGMKTR	SCF_FBXL2	0.8632
p.R2396M	DO41644	UCEC	ICGC	LQAAFRGMKTR	SCF_FBXL2	0.8632
p.R2383T	TCGA-CV-5430	HNSC	TCGA	LQAAFRGMKTR	SCF_FBXL2	0.1111
p.R2383T	DO14270	HNSC	ICGC	LQAAFRGMKTR	SCF_FBXL2	0.1111
p.R2396G	DO233867	GACA	ICGC	LQAAFRGMKTR	SCF_FBXL2	0.7568
p.G2397S	DO50729	ORCA	ICGC	LQAAFRGMKTR	SCF_FBXL2	0.6993
p.R2385I	SIDM00541	Colorectal Carcinoma	GDSC	LQAAFRGMKTR	SCF_FBXL2	0.1667
p.R2385I	ACH-000926	Colon/Colorectal Cancer	CCLE	LQAAFRGMKTR	SCF_FBXL2	0.1667
p.R2385I	HT55	large_intestine	COSMIC	LQAAFRGMKTR	SCF_FBXL2	0.1667
p.A2393T	SIDM00545	Melanoma	GDSC	LQAAFRGMKTR	SCF_FBXL2	0.6028
p.A2393T	ACH-000987	Skin Cancer	CCLE	LQAAFRGMKTR	SCF_FBXL2	0.6028
p.A2393T	Mewo	skin	COSMIC	LQAAFRGMKTR	SCF_FBXL2	0.6028
p.S2410F	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	LQAAFRGMKTR	SCF_FBXL2	0.0833
p.S2410F	ACH-000886	Lung Cancer	CCLE	LQAAFRGMKTR	SCF_FBXL2	0.0833
p.S2410F	NCI-H2009	lung	COSMIC	LQAAFRGMKTR	SCF_FBXL2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	SCF_FBXL2	2391:2401	LQAAFRGMKTR	FBXL2	0.5744	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons