DegronMD

Uniprot ID: Q8IZT6

Source protein: Abnormal spindle-like microcephaly-associated protein

Source gene: ASPM

Class: DEG_SPOP_SBC_1

Location: 564:568

E3 ligase: SPOP

DEGRON score: 0.9996

ASA_SCORE: 77.62

COIL: 0.8778

CONS_SCORE: 0.3163

DSS_SCORE: 0.5109

HELIX: 0.0816

FCONS_SCORE: 1.0831

RIG_SCORE: 0.6779

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K556N	TCGA-AG-A002	READ	TCGA	PSSTT	DEG_SPOP_SBC_1	0.2222
p.V571L	TCGA-BB-A5HY	HNSC	TCGA	PSSTT	DEG_SPOP_SBC_1	0.25
p.V571L	DO218979	HNSC	ICGC	PSSTT	DEG_SPOP_SBC_1	0.25
p.S557C	TCGA-BR-8080	STAD	TCGA	PSSTT	DEG_SPOP_SBC_1	0.1389
p.S557C	DO38651	STAD	ICGC	PSSTT	DEG_SPOP_SBC_1	0.1389
p.K556E	TCGA-CV-5435	HNSC	TCGA	PSSTT	DEG_SPOP_SBC_1	0.2222
p.K556E	DO14299	HNSC	ICGC	PSSTT	DEG_SPOP_SBC_1	0.2222
p.S565T	TCGA-CV-5973	HNSC	TCGA	PSSTT	DEG_SPOP_SBC_1	0.7116
p.S565T	DO15014	HNSC	ICGC	PSSTT	DEG_SPOP_SBC_1	0.7116
p.D578N	TCGA-EY-A1GD	UCEC	TCGA	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	DO42129	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM00194	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM00308	Chronic Myelogenous Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM00394	Cervical Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM00280	Gastric Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM01611	Endometrial Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM00500	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM00171	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM00016	Neuroblastoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM00162	Biliary Tract Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.D578N	SIDM01619	Endometrial Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.A572D	DO229018	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	0.2222
p.T568K	DO229026	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	0.7306
p.S566L	SIDM02021	Esophageal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.7667
p.S566L	SIDM00215	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.7667
p.S566L	ACH-000460	Ovarian Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	0.7667
p.S566L	ACH-000708	Colon/Colorectal Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	0.7667
p.S566L	SNU-283	large_intestine	COSMIC	PSSTT	DEG_SPOP_SBC_1	0.7667
p.R573W	SIDM01006	Plasma Cell Myeloma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.1944
p.R573W	SIDM00741	Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.1944
p.R573W	SIDM00522	Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.1944
p.R573W	SIDM00888	Other Solid Cancers	GDSC	PSSTT	DEG_SPOP_SBC_1	0.1944
p.R573W	SIDM00833	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.1944
p.S570L	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.7222
p.S570L	ACH-000744	Lung Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	0.7222
p.S570L	NCI-H1623	lung	COSMIC	PSSTT	DEG_SPOP_SBC_1	0.7222
p.R573Q	ACH-001523	Skin Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	279:283	PSSTT	SPOP	0.9606	More...
O75626	PR domain zinc finger protein 1	DEG_SPOP_SBC_1	330:334	PSSTT	SPOP	0.9804	More...
P10323	Acrosin	DEG_SPOP_SBC_1	372:376	PSSTT	SPOP	0.9214	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	389:393	PSSTT	SPOP	0.912	More...
P19801	Amiloride-sensitive amine oxidase [copper-containing]	DEG_SPOP_SBC_1	58:62	PSSTT	SPOP	0.6653	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	913:917	PSSTT	SPOP	0.9979	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1715:1719	PSSTT	SPOP	0.9877	More...
Q16186	Proteasomal ubiquitin receptor ADRM1	DEG_SPOP_SBC_1	218:222	PSSTT	SPOP	0.979	More...
Q6VAB6	Kinase suppressor of Ras 2	DEG_SPOP_SBC_1	521:525	PSSTT	SPOP	0.982	More...
Q8IVT5	Kinase suppressor of Ras 1	DEG_SPOP_SBC_1	448:452	PSSTT	SPOP	0.9811	More...
Q8IWE5	Pleckstrin homology domain-containing family M member 2	DEG_SPOP_SBC_1	379:383	PSSTT	SPOP	0.6967	More...
Q8IYB5	Stromal membrane-associated protein 1	DEG_SPOP_SBC_1	445:449	PSSTT	SPOP	0.9873	More...
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	DEG_SPOP_SBC_1	564:568	PSSTT	SPOP	0.9996	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2083:2087	PSSTT	SPOP	0.6521	More...
Q9BZ23	Pantothenate kinase 2, mitochondrial	DEG_SPOP_SBC_1	35:39	PSSTT	SPOP	0.9845	More...
Q9UBW5	Bridging integrator 2	DEG_SPOP_SBC_1	363:367	PSSTT	SPOP	0.9824	More...
Q6P4D5	PABIR family member 1	DEG_SPOP_SBC_1	14:18	PSSTT	SPOP	0.8064	More...
Q6UXX5	Inter-alpha-trypsin inhibitor heavy chain H6	DEG_SPOP_SBC_1	914:918	PSSTT	SPOP	0.5086	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	111:115	PSSTT	SPOP	0.8482	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	161:165	PSSTT	SPOP	0.9384	More...
Q9ULJ7	Ankyrin repeat domain-containing protein 50	DEG_SPOP_SBC_1	1235:1239	PSSTT	SPOP	0.9936	More...
Q9Y2D5	A-kinase anchor protein 2	DEG_SPOP_SBC_1	153:157	PSSTT	SPOP	0.9567	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1195:1199	PSSTT	SPOP	0.9043	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	351:355	PSSTT	SPOP	0.9888	More...
Q9HC44	Vasculin-like protein 1	DEG_SPOP_SBC_1	297:301	PSSTT	SPOP	0.9981	More...
Q9P2B7	Cilia- and flagella-associated protein 97	DEG_SPOP_SBC_1	234:238	PSSTT	SPOP	0.9913	More...
A6NM66	Uncharacterized protein encoded by LINC01548	DEG_SPOP_SBC_1	82:86	PSSTT	SPOP	0.6139	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTT

Degron related mutations and impact score

Drug responses associated with ASPM mutations

All proteins holding degron of PSSTT