DegronMD - Q9H1U4(MEGF9)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S179R	TCGA-CV-6941	HNSC	TCGA	VLPTPPAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.1667
p.P154Q	TCGA-CV-6959	HNSC	TCGA	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation rewiring degron network	0.2778
p.P154Q	TCGA-D3-A2J6	SKCM	TCGA	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation rewiring degron network	0.2778
p.P154Q	DO15406	HNSC	ICGC	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation rewiring degron network	0.2778
p.P154Q	DO37901	SKCM	ICGC	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation rewiring degron network	0.2778
p.R348C	TCGA-D1-A16X	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1944
p.R348C	TCGA-D8-A27G	BRCA	TCGA	AVTST	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1944
p.E101K	TCGA-D3-A8GI	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.E101K	DO50284	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.K363N	TCGA-D6-A74Q	HNSC	TCGA	AVTST	DEG_SPOP_SBC_1	353:357	Mutation substituting flanking lysine	0.2778
p.K363N	DO52087	HNSC	ICGC	AVTST	DEG_SPOP_SBC_1	353:357	Mutation substituting flanking lysine	0.2778
p.S196C	TCGA-DK-A3WW	BLCA	TCGA	VLPTPPAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.2222
p.S364L	TCGA-EO-A22X	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1389
p.P165S	TCGA-FW-A3R5	SKCM	TCGA	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation rewiring degron network	0.25
p.L120F	TCGA-SW-A7EA	STAD	TCGA	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.L120F	DO51749	STAD	ICGC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.S188C	DO481	BLCA	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	185:192	Mutation altering degron motif	0.7541
p.I362V	DO6358	CLLE	ICGC	AVTST	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1944
p.P195T	DO227996	COCA	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.25
p.S171R	DO15919	HNSC	ICGC	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation rewiring degron network	0.0833
p.S180R	DO229015	LICA	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.1944
p.P122H	DO229028	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1389
p.P202L	DO229036	LICA	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.0556
p.S356Y	DO229036	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.712
p.Q195P	DO23108	LINC	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.25
p.Q195P	DO45041	LINC	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.25
p.C360F	DO50713	ORCA	ICGC	AVTST	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.25
p.P157S	DO37406	SKCM	ICGC	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation altering degron motif	0.6752
p.A122V	DO229085	THCA	ICGC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1389
p.T157I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation altering degron motif	0.5966
p.T157I	ACH-000981	Leukemia	CCLE	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation altering degron motif	0.5966
p.T357I	SIDM00524	Small Cell Lung Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7078
p.T357I	ACH-000703	Lung Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7078
p.T357I	DMS-79	lung	COSMIC	AVTST	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7078
p.S112A	SIDM01090	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM01117	Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00087	Plasma Cell Myeloma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00690	Head and Neck Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00210	Ovarian Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00311	Mesothelioma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00529	Breast Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00879	Breast Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM01133	Other Solid Cancers	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00863	Burkitt's Lymphoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM01681	Non-Cancerous	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00944	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00720	Mesothelioma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00673	Breast Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM00760	Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S112A	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.6477
p.S113A	SIDM00568	Gastric Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.7588
p.S113A	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.7588
p.G153V	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation rewiring degron network	0.25
p.G153V	ACH-000878	Lung Cancer	CCLE	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation rewiring degron network	0.25
p.G153V	HCC-15	lung	COSMIC	PTTPVAT	DEG_SCF_FBW7_1	156:162	Mutation rewiring degron network	0.25
p.S184N	SIDM01591	Breast Carcinoma	GDSC	VLPTPPAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.3056
p.S184N	ACH-000540	Non-Cancerous	CCLE	VLPTPPAT	DEG_SCF_FBW7_1	185:192	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEGF9

UniProt ID: Q9H1U4

Entrez ID: 1955

Protein name: Multiple epidermal growth factor-like domains protein 9 (Multiple EGF-like domains protein 9) (Epidermal growth factor-like protein 5) (EGF-like protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEGF9 in